Swelling Behavior of Glucose Sensitive Membranes

Thomas A. Horbett; Joseph Kost; Buddy D. Ratner

doi:10.1007/978-1-4613-2433-1_14

Swelling Behavior of Glucose Sensitive Membranes

Thomas A. Horbett, Joseph Kost, Buddy D. Ratner

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

27 Scopus citations

Abstract

Polymers which are sensitive to their environment may be useful as metabolic sensors. Because of the great need for a glucose sensor which could be used in vivo to enhance treatment of diabetics, we are developing membranes responsive to glucose by incorporating glucose oxidase into amine-containing polymers. The conversion of glucose into gluconic acid in the membrane causes increased protonation of the membrane, resulting in increased membrane swelling. This paper describes the preparation and swelling properties of glucose sensitive membranes of this type.

Original language	English
Title of host publication	Polymers as Biomaterials
Editors	Shalaby W. Shalaby, Allan S. Hoffman, Buddy D. Ratner, Thomas A. Horbett
Publisher	Plenum Press
Pages	193-207
Number of pages	15
ISBN (Print)	030641886X, 9780306418860
DOIs	https://doi.org/10.1007/978-1-4613-2433-1_14
State	Published - 1984
Externally published	Yes

ASJC Scopus subject areas

General Engineering

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10.1007/978-1-4613-2433-1_14

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title = "Swelling Behavior of Glucose Sensitive Membranes",

abstract = "Polymers which are sensitive to their environment may be useful as metabolic sensors. Because of the great need for a glucose sensor which could be used in vivo to enhance treatment of diabetics, we are developing membranes responsive to glucose by incorporating glucose oxidase into amine-containing polymers. The conversion of glucose into gluconic acid in the membrane causes increased protonation of the membrane, resulting in increased membrane swelling. This paper describes the preparation and swelling properties of glucose sensitive membranes of this type.",

author = "Horbett, {Thomas A.} and Joseph Kost and Ratner, {Buddy D.}",

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AU - Kost, Joseph

AU - Ratner, Buddy D.

PY - 1984

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AB - Polymers which are sensitive to their environment may be useful as metabolic sensors. Because of the great need for a glucose sensor which could be used in vivo to enhance treatment of diabetics, we are developing membranes responsive to glucose by incorporating glucose oxidase into amine-containing polymers. The conversion of glucose into gluconic acid in the membrane causes increased protonation of the membrane, resulting in increased membrane swelling. This paper describes the preparation and swelling properties of glucose sensitive membranes of this type.

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U2 - 10.1007/978-1-4613-2433-1_14

DO - 10.1007/978-1-4613-2433-1_14

M3 - Conference contribution

AN - SCOPUS:0021572029

SN - 030641886X

SN - 9780306418860

SP - 193

EP - 207

BT - Polymers as Biomaterials

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A2 - Ratner, Buddy D.

A2 - Horbett, Thomas A.

PB - Plenum Press

ER -

Swelling Behavior of Glucose Sensitive Membranes

Abstract

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