Synapsins and Regulation of the Reserve Pool

D. Gitler, G. J. Augustine

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

Synaptic transmission relies on the release of neurotransmitters that are stored in synaptic vesicles (SVs). Neurotransmitters are released by the calcium-regulated fusion of these SVs with the plasma membrane. The speed, fidelity, and plasticity of synaptic transmission rely on the availability of SVs, which in turn is determined by the allocation of SVs into multiple pools that differ in their readiness for release. This article describes the role that synapsins play in management of these pools and reconstitution of SVs following fusion.

Original languageEnglish
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd.
Pages709-717
Number of pages9
ISBN (Print)9780080450469
DOIs
StatePublished - 1 Jan 2009

Keywords

  • Presynaptic proteins
  • Synapse
  • Synapsin
  • Synaptic depression
  • Synaptic plasticity
  • Synaptic transmission
  • Synaptic vesicle
  • Vesicle pools
  • Vesicle trafficking

ASJC Scopus subject areas

  • Neuroscience (all)

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