Synapsins and Regulation of the Reserve Pool

D. Gitler; G. J. Augustine

doi:10.1016/B978-008045046-9.01776-9

Synapsins and Regulation of the Reserve Pool

D. Gitler, G. J. Augustine

Physiology and Cell Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Synaptic transmission relies on the release of neurotransmitters that are stored in synaptic vesicles (SVs). Neurotransmitters are released by the calcium-regulated fusion of these SVs with the plasma membrane. The speed, fidelity, and plasticity of synaptic transmission rely on the availability of SVs, which in turn is determined by the allocation of SVs into multiple pools that differ in their readiness for release. This article describes the role that synapsins play in management of these pools and reconstitution of SVs following fusion.

Original language	English
Title of host publication	Encyclopedia of Neuroscience
Publisher	Elsevier Ltd.
Pages	709-717
Number of pages	9
ISBN (Print)	9780080450469
DOIs	https://doi.org/10.1016/B978-008045046-9.01776-9
State	Published - 1 Jan 2009

Keywords

Presynaptic proteins
Synapse
Synapsin
Synaptic depression
Synaptic plasticity
Synaptic transmission
Synaptic vesicle
Vesicle pools
Vesicle trafficking

ASJC Scopus subject areas

General Neuroscience

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10.1016/B978-008045046-9.01776-9

Cite this

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AB - Synaptic transmission relies on the release of neurotransmitters that are stored in synaptic vesicles (SVs). Neurotransmitters are released by the calcium-regulated fusion of these SVs with the plasma membrane. The speed, fidelity, and plasticity of synaptic transmission rely on the availability of SVs, which in turn is determined by the allocation of SVs into multiple pools that differ in their readiness for release. This article describes the role that synapsins play in management of these pools and reconstitution of SVs following fusion.

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KW - Synapsin

KW - Synaptic depression

KW - Synaptic plasticity

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KW - Vesicle pools

KW - Vesicle trafficking

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PB - Elsevier Ltd.

ER -

Synapsins and Regulation of the Reserve Pool

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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