Synapsins and Regulation of the Reserve Pool

D. Gitler; G. J. Augustine

doi:10.1016/B978-008045046-9.01776-9

Synapsins and Regulation of the Reserve Pool

D. Gitler
, G. J. Augustine

Physiology and Cell Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Synaptic transmission relies on the release of neurotransmitters that are stored in synaptic vesicles (SVs). Neurotransmitters are released by the calcium-regulated fusion of these SVs with the plasma membrane. The speed, fidelity, and plasticity of synaptic transmission rely on the availability of SVs, which in turn is determined by the allocation of SVs into multiple pools that differ in their readiness for release. This article describes the role that synapsins play in management of these pools and reconstitution of SVs following fusion.

Original language	English
Title of host publication	Encyclopedia of Neuroscience
Subtitle of host publication	Volumes 1-11
Publisher	Elsevier
Pages	V10-709-V10-717
Volume	10
ISBN (Electronic)	9780080450469
ISBN (Print)	9780080446172
DOIs	https://doi.org/10.1016/B978-008045046-9.01776-9
State	Published - 1 Jan 2009

Keywords

Presynaptic proteins
Synapse
Synapsin
Synaptic depression
Synaptic plasticity
Synaptic transmission
Synaptic vesicle
Vesicle pools
Vesicle trafficking

ASJC Scopus subject areas

General Medicine
General Neuroscience

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10.1016/B978-008045046-9.01776-9

Cite this

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AB - Synaptic transmission relies on the release of neurotransmitters that are stored in synaptic vesicles (SVs). Neurotransmitters are released by the calcium-regulated fusion of these SVs with the plasma membrane. The speed, fidelity, and plasticity of synaptic transmission rely on the availability of SVs, which in turn is determined by the allocation of SVs into multiple pools that differ in their readiness for release. This article describes the role that synapsins play in management of these pools and reconstitution of SVs following fusion.

KW - Presynaptic proteins

KW - Synapse

KW - Synapsin

KW - Synaptic depression

KW - Synaptic plasticity

KW - Synaptic transmission

KW - Synaptic vesicle

KW - Vesicle pools

KW - Vesicle trafficking

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VL - 10

SP - V10-709-V10-717

BT - Encyclopedia of Neuroscience

PB - Elsevier

ER -

Synapsins and Regulation of the Reserve Pool

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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