Synapsins regulate α-synuclein functions

Merav Atias, Yaara Tevet, Jichao Sun, Alexandra Stavsky, Shani Tal, Joy Kahn, Subhojit Roy, Daniel Gitler

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

The normal function of α-synuclein (α-syn) remains elusive. Although recent studies suggest α-syn as a physiologic attenuator of synaptic vesicle (SV) recycling, mechanisms are unclear. Here, we show that synapsin—a cytosolic protein with known roles in SV mobilization and clustering—is required for presynaptic functions of α-syn. Our data offer a critical missing link and advocate a model where α-syn and synapsin cooperate to cluster SVs and attenuate recycling.

Original languageEnglish
Pages (from-to)11116-11118
Number of pages3
JournalProceedings of the National Academy of Sciences of the United States of America
Volume166
Issue number23
DOIs
StatePublished - 4 Jun 2019

Keywords

  • Alpha synuclein
  • Neurotransmission
  • Synapsin

ASJC Scopus subject areas

  • General

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