Synapsins regulate α-synuclein functions

Merav Atias; Yaara Tevet; Jichao Sun; Alexandra Stavsky; Shani Tal; Joy Kahn; Subhojit Roy; Daniel Gitler

doi:10.1073/pnas.1903054116

Synapsins regulate α-synuclein functions

Merav Atias, Yaara Tevet, Jichao Sun, Alexandra Stavsky, Shani Tal, Joy Kahn, Subhojit Roy, Daniel Gitler

Department of Physiology and Cell Biology

Research output: Contribution to journal › Article › peer-review

77 Scopus citations

Abstract

The normal function of α-synuclein (α-syn) remains elusive. Although recent studies suggest α-syn as a physiologic attenuator of synaptic vesicle (SV) recycling, mechanisms are unclear. Here, we show that synapsin—a cytosolic protein with known roles in SV mobilization and clustering—is required for presynaptic functions of α-syn. Our data offer a critical missing link and advocate a model where α-syn and synapsin cooperate to cluster SVs and attenuate recycling.

Original language	English
Pages (from-to)	11116-11118
Number of pages	3
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	166
Issue number	23
DOIs	https://doi.org/10.1073/pnas.1903054116
State	Published - 4 Jun 2019

Keywords

Alpha synuclein
Neurotransmission
Synapsin

ASJC Scopus subject areas

General

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10.1073/pnas.1903054116

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title = "Synapsins regulate α-synuclein functions",

abstract = "The normal function of α-synuclein (α-syn) remains elusive. Although recent studies suggest α-syn as a physiologic attenuator of synaptic vesicle (SV) recycling, mechanisms are unclear. Here, we show that synapsin—a cytosolic protein with known roles in SV mobilization and clustering—is required for presynaptic functions of α-syn. Our data offer a critical missing link and advocate a model where α-syn and synapsin cooperate to cluster SVs and attenuate recycling.",

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author = "Merav Atias and Yaara Tevet and Jichao Sun and Alexandra Stavsky and Shani Tal and Joy Kahn and Subhojit Roy and Daniel Gitler",

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T1 - Synapsins regulate α-synuclein functions

AU - Atias, Merav

AU - Tevet, Yaara

AU - Sun, Jichao

AU - Stavsky, Alexandra

AU - Tal, Shani

AU - Kahn, Joy

AU - Roy, Subhojit

AU - Gitler, Daniel

PY - 2019/6/4

Y1 - 2019/6/4

N2 - The normal function of α-synuclein (α-syn) remains elusive. Although recent studies suggest α-syn as a physiologic attenuator of synaptic vesicle (SV) recycling, mechanisms are unclear. Here, we show that synapsin—a cytosolic protein with known roles in SV mobilization and clustering—is required for presynaptic functions of α-syn. Our data offer a critical missing link and advocate a model where α-syn and synapsin cooperate to cluster SVs and attenuate recycling.

AB - The normal function of α-synuclein (α-syn) remains elusive. Although recent studies suggest α-syn as a physiologic attenuator of synaptic vesicle (SV) recycling, mechanisms are unclear. Here, we show that synapsin—a cytosolic protein with known roles in SV mobilization and clustering—is required for presynaptic functions of α-syn. Our data offer a critical missing link and advocate a model where α-syn and synapsin cooperate to cluster SVs and attenuate recycling.

KW - Alpha synuclein

KW - Neurotransmission

KW - Synapsin

UR - https://www.scopus.com/pages/publications/85066626058

U2 - 10.1073/pnas.1903054116

DO - 10.1073/pnas.1903054116

M3 - Article

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AN - SCOPUS:85066626058

SN - 0027-8424

VL - 166

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EP - 11118

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 23

ER -

Synapsins regulate α-synuclein functions

Abstract

Keywords

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