Synergistic activation of quorum sensing in Vibrio harveyi

Aviad Mandabi, Hadas Ganin, Michael M. Meijler

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Abstract Autoinducer-2 (AI-2) has been suggested to serve as a ubiquitous quorum sensing (QS) signal that mediates intra- and interspecies cross-talk between bacteria. To add tools for the study of its function in bacterial communication, we present a new and an improved synthetic route to AI-2 and aromatic analogues. We used this strategy to prepare naphthyl-DPD, and observed remarkably high synergistic activity at low nanomolar concentrations for this analogue in Vibrio harveyi.

Original languageEnglish
Article number22917
Pages (from-to)3966-3969
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number18
StatePublished - 17 Aug 2015
Externally publishedYes


  • AI-2
  • DPD
  • Quorum sensing
  • V. harveyi

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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