Synergistic activation of quorum sensing in Vibrio harveyi

Aviad Mandabi; Hadas Ganin; Michael M. Meijler

doi:10.1016/j.bmcl.2015.07.028

Synergistic activation of quorum sensing in Vibrio harveyi

Aviad Mandabi, Hadas Ganin, Michael M. Meijler

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Abstract Autoinducer-2 (AI-2) has been suggested to serve as a ubiquitous quorum sensing (QS) signal that mediates intra- and interspecies cross-talk between bacteria. To add tools for the study of its function in bacterial communication, we present a new and an improved synthetic route to AI-2 and aromatic analogues. We used this strategy to prepare naphthyl-DPD, and observed remarkably high synergistic activity at low nanomolar concentrations for this analogue in Vibrio harveyi.

Original language	English
Article number	22917
Pages (from-to)	3966-3969
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	25
Issue number	18
DOIs	https://doi.org/10.1016/j.bmcl.2015.07.028
State	Published - 17 Aug 2015

Keywords

AI-2
DPD
Quorum sensing
V. harveyi

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2015.07.028

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title = "Synergistic activation of quorum sensing in Vibrio harveyi",

abstract = "Abstract Autoinducer-2 (AI-2) has been suggested to serve as a ubiquitous quorum sensing (QS) signal that mediates intra- and interspecies cross-talk between bacteria. To add tools for the study of its function in bacterial communication, we present a new and an improved synthetic route to AI-2 and aromatic analogues. We used this strategy to prepare naphthyl-DPD, and observed remarkably high synergistic activity at low nanomolar concentrations for this analogue in Vibrio harveyi.",

keywords = "AI-2, DPD, Quorum sensing, V. harveyi",

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AU - Ganin, Hadas

AU - Meijler, Michael M.

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AB - Abstract Autoinducer-2 (AI-2) has been suggested to serve as a ubiquitous quorum sensing (QS) signal that mediates intra- and interspecies cross-talk between bacteria. To add tools for the study of its function in bacterial communication, we present a new and an improved synthetic route to AI-2 and aromatic analogues. We used this strategy to prepare naphthyl-DPD, and observed remarkably high synergistic activity at low nanomolar concentrations for this analogue in Vibrio harveyi.

KW - AI-2

KW - DPD

KW - Quorum sensing

KW - V. harveyi

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ER -

Synergistic activation of quorum sensing in Vibrio harveyi

Abstract

Keywords

ASJC Scopus subject areas

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