Syntheses relevant to vitamin B12 biosynthesis: Synthesis of sirohydrochlorin and of its octamethyl ester

Michael H. Block; Steven C. Zimmerman; Graeme B. Henderson; Simon P.D. Turner; Steven W. Westwood; Finian J. Leeper; Alan R. Battersby

doi:10.1039/c39850001061

Syntheses relevant to vitamin B₁₂ biosynthesis: Synthesis of sirohydrochlorin and of its octamethyl ester

Michael H. Block, Steven C. Zimmerman, Graeme B. Henderson, Simon P.D. Turner, Steven W. Westwood, Finian J. Leeper, Alan R. Battersby

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Abstract

Sirohydrochlorin is an isobacteriochlorin isolated (a) as the metal-free prosthetic group of sulphite reductase and (b) as the aromatised form of the di-C-methylated intermediate on the biosynthetic pathway to vitamin B ₁₂; the synthesis is described of the natural enantiomer of sirohydrochlorin and also of its octamethyl ester using a mild photochemical route.

Original language	English
Pages (from-to)	1061-1063
Number of pages	3
Journal	Chemical Communications
Issue number	16
DOIs	https://doi.org/10.1039/c39850001061
State	Published - 1 Jan 1985
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine

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abstract = "Sirohydrochlorin is an isobacteriochlorin isolated (a) as the metal-free prosthetic group of sulphite reductase and (b) as the aromatised form of the di-C-methylated intermediate on the biosynthetic pathway to vitamin B 12; the synthesis is described of the natural enantiomer of sirohydrochlorin and also of its octamethyl ester using a mild photochemical route.",

author = "Block, {Michael H.} and Zimmerman, {Steven C.} and Henderson, {Graeme B.} and Turner, {Simon P.D.} and Westwood, {Steven W.} and Leeper, {Finian J.} and Battersby, {Alan R.}",

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AU - Block, Michael H.

AU - Zimmerman, Steven C.

AU - Henderson, Graeme B.

AU - Turner, Simon P.D.

AU - Westwood, Steven W.

AU - Leeper, Finian J.

AU - Battersby, Alan R.

PY - 1985/1/1

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N2 - Sirohydrochlorin is an isobacteriochlorin isolated (a) as the metal-free prosthetic group of sulphite reductase and (b) as the aromatised form of the di-C-methylated intermediate on the biosynthetic pathway to vitamin B 12; the synthesis is described of the natural enantiomer of sirohydrochlorin and also of its octamethyl ester using a mild photochemical route.

AB - Sirohydrochlorin is an isobacteriochlorin isolated (a) as the metal-free prosthetic group of sulphite reductase and (b) as the aromatised form of the di-C-methylated intermediate on the biosynthetic pathway to vitamin B 12; the synthesis is described of the natural enantiomer of sirohydrochlorin and also of its octamethyl ester using a mild photochemical route.

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Syntheses relevant to vitamin B₁₂ biosynthesis: Synthesis of sirohydrochlorin and of its octamethyl ester

Abstract

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