Syntheses relevant to vitamin B12 biosynthesis: Synthesis of sirohydrochlorin and of its octamethyl ester

Michael H. Block; Steven C. Zimmerman; Graeme B. Henderson; Simon P.D. Turner; Steven W. Westwood; Finian J. Leeper; Alan R. Battersby

doi:10.1039/c39850001061

Syntheses relevant to vitamin B₁₂ biosynthesis: Synthesis of sirohydrochlorin and of its octamethyl ester

Michael H. Block, Steven C. Zimmerman, Graeme B. Henderson, Simon P.D. Turner, Steven W. Westwood, Finian J. Leeper, Alan R. Battersby

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33 Scopus citations

Abstract

Sirohydrochlorin is an isobacteriochlorin isolated (a) as the metal-free prosthetic group of sulphite reductase and (b) as the aromatised form of the di-C-methylated intermediate on the biosynthetic pathway to vitamin B ₁₂; the synthesis is described of the natural enantiomer of sirohydrochlorin and also of its octamethyl ester using a mild photochemical route.

Original language	English
Pages (from-to)	1061-1063
Number of pages	3
Journal	Chemical Communications
Issue number	16
DOIs	https://doi.org/10.1039/c39850001061
State	Published - 1 Jan 1985
Externally published	Yes

ASJC Scopus subject areas

Molecular Medicine

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title = "Syntheses relevant to vitamin B12 biosynthesis: Synthesis of sirohydrochlorin and of its octamethyl ester",

abstract = "Sirohydrochlorin is an isobacteriochlorin isolated (a) as the metal-free prosthetic group of sulphite reductase and (b) as the aromatised form of the di-C-methylated intermediate on the biosynthetic pathway to vitamin B 12; the synthesis is described of the natural enantiomer of sirohydrochlorin and also of its octamethyl ester using a mild photochemical route.",

author = "Block, \{Michael H.\} and Zimmerman, \{Steven C.\} and Henderson, \{Graeme B.\} and Turner, \{Simon P.D.\} and Westwood, \{Steven W.\} and Leeper, \{Finian J.\} and Battersby, \{Alan R.\}",

year = "1985",

month = jan,

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doi = "10.1039/c39850001061",

language = "English",

pages = "1061--1063",

journal = "Chemical Communications",

issn = "0022-4936",

publisher = "Royal Society of Chemistry",

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T1 - Syntheses relevant to vitamin B12 biosynthesis

T2 - Synthesis of sirohydrochlorin and of its octamethyl ester

AU - Block, Michael H.

AU - Zimmerman, Steven C.

AU - Henderson, Graeme B.

AU - Turner, Simon P.D.

AU - Westwood, Steven W.

AU - Leeper, Finian J.

AU - Battersby, Alan R.

PY - 1985/1/1

Y1 - 1985/1/1

N2 - Sirohydrochlorin is an isobacteriochlorin isolated (a) as the metal-free prosthetic group of sulphite reductase and (b) as the aromatised form of the di-C-methylated intermediate on the biosynthetic pathway to vitamin B 12; the synthesis is described of the natural enantiomer of sirohydrochlorin and also of its octamethyl ester using a mild photochemical route.

AB - Sirohydrochlorin is an isobacteriochlorin isolated (a) as the metal-free prosthetic group of sulphite reductase and (b) as the aromatised form of the di-C-methylated intermediate on the biosynthetic pathway to vitamin B 12; the synthesis is described of the natural enantiomer of sirohydrochlorin and also of its octamethyl ester using a mild photochemical route.

UR - https://www.scopus.com/pages/publications/0021810470

U2 - 10.1039/c39850001061

DO - 10.1039/c39850001061

M3 - Article

AN - SCOPUS:0021810470

SN - 0022-4936

SP - 1061

EP - 1063

JO - Chemical Communications

JF - Chemical Communications

IS - 16

ER -

Syntheses relevant to vitamin B₁₂ biosynthesis: Synthesis of sirohydrochlorin and of its octamethyl ester

Abstract

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