Synthesis and biological validation of a ubiquitous quorum-sensing molecule

Michael M. Meijler, Louis G. Hom, Gunnar F. Kaufmann, Kathleen M. McKenzie, Chengzao Sun, Jason A. Moss, Masayuki Matsushita, Kim D. Janda

Research output: Contribution to journalArticlepeer-review

83 Scopus citations

Abstract

Chemical communication ("quorum sensing") amongst bacteria has been studied by the synthesis and study of enantiopure (R)-4,5-dihydroxy-2,3- pentanedione (DPD, see scheme). Bioactivity assays with DPD have shown that chelation of boron by the cyclic form of DPD appears to be essential for full induction of bioluminescence, which is an example of quorum-sensing-controlled behavior.

Original languageEnglish
Pages (from-to)2106-2108
Number of pages3
JournalAngewandte Chemie - International Edition
Volume43
Issue number16
DOIs
StatePublished - 13 Apr 2004
Externally publishedYes

Keywords

  • Autoinducers
  • Bioluminescence
  • Molecular recognition
  • Sensors
  • Signal transduction

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry

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