Synthesis and biological validation of a ubiquitous quorum-sensing molecule

Michael M. Meijler; Louis G. Hom; Gunnar F. Kaufmann; Kathleen M. McKenzie; Chengzao Sun; Jason A. Moss; Masayuki Matsushita; Kim D. Janda

doi:10.1002/anie.200353150

Synthesis and biological validation of a ubiquitous quorum-sensing molecule

Michael M. Meijler, Louis G. Hom, Gunnar F. Kaufmann, Kathleen M. McKenzie, Chengzao Sun, Jason A. Moss, Masayuki Matsushita, Kim D. Janda

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

Chemical communication ("quorum sensing") amongst bacteria has been studied by the synthesis and study of enantiopure (R)-4,5-dihydroxy-2,3- pentanedione (DPD, see scheme). Bioactivity assays with DPD have shown that chelation of boron by the cyclic form of DPD appears to be essential for full induction of bioluminescence, which is an example of quorum-sensing-controlled behavior.

Original language	English
Pages (from-to)	2106-2108
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	43
Issue number	16
DOIs	https://doi.org/10.1002/anie.200353150
State	Published - 13 Apr 2004
Externally published	Yes

Keywords

Autoinducers
Bioluminescence
Molecular recognition
Sensors
Signal transduction

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.200353150

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AU - Hom, Louis G.

AU - Kaufmann, Gunnar F.

AU - McKenzie, Kathleen M.

AU - Sun, Chengzao

AU - Moss, Jason A.

AU - Matsushita, Masayuki

AU - Janda, Kim D.

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KW - Autoinducers

KW - Bioluminescence

KW - Molecular recognition

KW - Sensors

KW - Signal transduction

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Synthesis and biological validation of a ubiquitous quorum-sensing molecule

Abstract

Keywords

ASJC Scopus subject areas

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