Synthesis and characterization of biodegradable copolyesters and copolyanhydrides prepared from fumaric and succinic acid trimers and oligomers

Shimon Ben-Shabat; Omar Elmalak; Abraham Nyska; Abraham J. Domb

doi:10.1560/EDR4-8FC1-CQ8M-J6RL

Synthesis and characterization of biodegradable copolyesters and copolyanhydrides prepared from fumaric and succinic acid trimers and oligomers

Shimon Ben-Shabat, Omar Elmalak, Abraham Nyska, Abraham J. Domb

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3 Scopus citations

Abstract

A series of new biodegradable copolymers and copolyanhydrides built of trimers of fumaric and succinic acid and propylene glycol, covering a wide range of compositions, were prepared and characterized for use as drug carriers. The polymers were found to degrade within a period of weeks. Polyanhydrides loaded with ibuprofen as a model drug released the drug for a period of one week, while the polyesters released the drug for more then 30 days. The biocompatibility and the rate of evacuation of trimer-based polymers of fumaric and succinic acids were investigated in rats. All polymers were found compatible when implanted in mice.

Original language	English
Pages (from-to)	411-420
Number of pages	10
Journal	Israel Journal of Chemistry
Volume	45
Issue number	4
DOIs	https://doi.org/10.1560/EDR4-8FC1-CQ8M-J6RL
State	Published - 29 Nov 2005

ASJC Scopus subject areas

General Chemistry

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abstract = "A series of new biodegradable copolymers and copolyanhydrides built of trimers of fumaric and succinic acid and propylene glycol, covering a wide range of compositions, were prepared and characterized for use as drug carriers. The polymers were found to degrade within a period of weeks. Polyanhydrides loaded with ibuprofen as a model drug released the drug for a period of one week, while the polyesters released the drug for more then 30 days. The biocompatibility and the rate of evacuation of trimer-based polymers of fumaric and succinic acids were investigated in rats. All polymers were found compatible when implanted in mice.",

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AU - Nyska, Abraham

AU - Domb, Abraham J.

PY - 2005/11/29

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AB - A series of new biodegradable copolymers and copolyanhydrides built of trimers of fumaric and succinic acid and propylene glycol, covering a wide range of compositions, were prepared and characterized for use as drug carriers. The polymers were found to degrade within a period of weeks. Polyanhydrides loaded with ibuprofen as a model drug released the drug for a period of one week, while the polyesters released the drug for more then 30 days. The biocompatibility and the rate of evacuation of trimer-based polymers of fumaric and succinic acids were investigated in rats. All polymers were found compatible when implanted in mice.

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Synthesis and characterization of biodegradable copolyesters and copolyanhydrides prepared from fumaric and succinic acid trimers and oligomers

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