Abstract
A series of new biodegradable copolymers and copolyanhydrides built of trimers of fumaric and succinic acid and propylene glycol, covering a wide range of compositions, were prepared and characterized for use as drug carriers. The polymers were found to degrade within a period of weeks. Polyanhydrides loaded with ibuprofen as a model drug released the drug for a period of one week, while the polyesters released the drug for more then 30 days. The biocompatibility and the rate of evacuation of trimer-based polymers of fumaric and succinic acids were investigated in rats. All polymers were found compatible when implanted in mice.
| Original language | English |
|---|---|
| Pages (from-to) | 411-420 |
| Number of pages | 10 |
| Journal | Israel Journal of Chemistry |
| Volume | 45 |
| Issue number | 4 |
| DOIs | |
| State | Published - 29 Nov 2005 |
ASJC Scopus subject areas
- General Chemistry
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