Synthesis and Conjugation of Alkyne-Functional Hyperbranched Polyglycerols

Eli Moore, Andrew T. Zill, Cyrus A. Anderson, Aljosha R. Jochem, Steven C. Zimmerman, Claudine S. Bonder, Tobias Kraus, Helmut Thissen, Nicolas H. Voelcker

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


This study outlines the synthetic and purification process used to obtain hyperbranched polyglycerol (HPG) within a molecular weight range not previously obtainable. Purified fractions with low polydispersity are achieved via successive precipitations from acetone. Furthermore, the use of the initiator molecule 5-hexyne-1-ol introduces alkyne functionality at the core of each HPG molecule. Alkyne-azide cycloaddition chemistry in combination with NMR and field flow fractionation analysis is used to verify the availability of the alkyne core for bioconjugation across the range of molecular weights. (Figure presented.).

Original languageEnglish
Pages (from-to)2252-2261
Number of pages10
JournalMacromolecular Chemistry and Physics
Issue number20
StatePublished - 1 Oct 2016
Externally publishedYes


  • bioconjugation
  • click reaction
  • hyperbranched polymers

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry


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