Synthesis and Conjugation of Alkyne-Functional Hyperbranched Polyglycerols

Eli Moore; Andrew T. Zill; Cyrus A. Anderson; Aljosha R. Jochem; Steven C. Zimmerman; Claudine S. Bonder; Tobias Kraus; Helmut Thissen; Nicolas H. Voelcker

doi:10.1002/macp.201500507

Synthesis and Conjugation of Alkyne-Functional Hyperbranched Polyglycerols

Eli Moore, Andrew T. Zill, Cyrus A. Anderson, Aljosha R. Jochem, Steven C. Zimmerman, Claudine S. Bonder, Tobias Kraus, Helmut Thissen, Nicolas H. Voelcker

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

This study outlines the synthetic and purification process used to obtain hyperbranched polyglycerol (HPG) within a molecular weight range not previously obtainable. Purified fractions with low polydispersity are achieved via successive precipitations from acetone. Furthermore, the use of the initiator molecule 5-hexyne-1-ol introduces alkyne functionality at the core of each HPG molecule. Alkyne-azide cycloaddition chemistry in combination with NMR and field flow fractionation analysis is used to verify the availability of the alkyne core for bioconjugation across the range of molecular weights. (Figure presented.).

Original language	English
Pages (from-to)	2252-2261
Number of pages	10
Journal	Macromolecular Chemistry and Physics
Volume	217
Issue number	20
DOIs	https://doi.org/10.1002/macp.201500507
State	Published - 1 Oct 2016
Externally published	Yes

Keywords

bioconjugation
click reaction
hyperbranched polymers

ASJC Scopus subject areas

Condensed Matter Physics
Physical and Theoretical Chemistry
Organic Chemistry
Polymers and Plastics
Materials Chemistry

Access to Document

10.1002/macp.201500507

Cite this

@article{99600e4790614b9db03805f3bd373af9,

title = "Synthesis and Conjugation of Alkyne-Functional Hyperbranched Polyglycerols",

abstract = "This study outlines the synthetic and purification process used to obtain hyperbranched polyglycerol (HPG) within a molecular weight range not previously obtainable. Purified fractions with low polydispersity are achieved via successive precipitations from acetone. Furthermore, the use of the initiator molecule 5-hexyne-1-ol introduces alkyne functionality at the core of each HPG molecule. Alkyne-azide cycloaddition chemistry in combination with NMR and field flow fractionation analysis is used to verify the availability of the alkyne core for bioconjugation across the range of molecular weights. (Figure presented.).",

keywords = "bioconjugation, click reaction, hyperbranched polymers",

author = "Eli Moore and Zill, {Andrew T.} and Anderson, {Cyrus A.} and Jochem, {Aljosha R.} and Zimmerman, {Steven C.} and Bonder, {Claudine S.} and Tobias Kraus and Helmut Thissen and Voelcker, {Nicolas H.}",

note = "Publisher Copyright: {\textcopyright} 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2016",

month = oct,

day = "1",

doi = "10.1002/macp.201500507",

language = "English",

volume = "217",

pages = "2252--2261",

journal = "Macromolecular Chemistry and Physics",

issn = "1022-1352",

publisher = "Wiley-VCH Verlag",

number = "20",

}

TY - JOUR

T1 - Synthesis and Conjugation of Alkyne-Functional Hyperbranched Polyglycerols

AU - Moore, Eli

AU - Zill, Andrew T.

AU - Anderson, Cyrus A.

AU - Jochem, Aljosha R.

AU - Zimmerman, Steven C.

AU - Bonder, Claudine S.

AU - Kraus, Tobias

AU - Thissen, Helmut

AU - Voelcker, Nicolas H.

PY - 2016/10/1

Y1 - 2016/10/1

N2 - This study outlines the synthetic and purification process used to obtain hyperbranched polyglycerol (HPG) within a molecular weight range not previously obtainable. Purified fractions with low polydispersity are achieved via successive precipitations from acetone. Furthermore, the use of the initiator molecule 5-hexyne-1-ol introduces alkyne functionality at the core of each HPG molecule. Alkyne-azide cycloaddition chemistry in combination with NMR and field flow fractionation analysis is used to verify the availability of the alkyne core for bioconjugation across the range of molecular weights. (Figure presented.).

AB - This study outlines the synthetic and purification process used to obtain hyperbranched polyglycerol (HPG) within a molecular weight range not previously obtainable. Purified fractions with low polydispersity are achieved via successive precipitations from acetone. Furthermore, the use of the initiator molecule 5-hexyne-1-ol introduces alkyne functionality at the core of each HPG molecule. Alkyne-azide cycloaddition chemistry in combination with NMR and field flow fractionation analysis is used to verify the availability of the alkyne core for bioconjugation across the range of molecular weights. (Figure presented.).

KW - bioconjugation

KW - click reaction

KW - hyperbranched polymers

UR - http://www.scopus.com/inward/record.url?scp=84960192255&partnerID=8YFLogxK

U2 - 10.1002/macp.201500507

DO - 10.1002/macp.201500507

M3 - Article

AN - SCOPUS:84960192255

SN - 1022-1352

VL - 217

SP - 2252

EP - 2261

JO - Macromolecular Chemistry and Physics

JF - Macromolecular Chemistry and Physics

IS - 20

ER -

Synthesis and Conjugation of Alkyne-Functional Hyperbranched Polyglycerols

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this