Synthesis and evaluation of a tag-free photoactive phospho-ceramide analogue-1 (PCERA-1) probe to study immunomodulation in macrophages

Rambabu Dandela, Roi Mashiach, Raju Adepu, Rachel Gregor, Muhammad Athamna, Efrat Zecharia, Orna Ernst, Tsaffrir Zor, Michael M. Meijler

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Phospho-ceramide analogue-1 (PCERA-1), a synthetic analogue of ceramide-1-phosphate (C1P), has been previously shown to act as a potent modulator of macrophage activity and inflammation. We have developed an efficient synthesis of PCERA-1 from readily available starting materials, and designed and prepared derivatives of this analogue, including a photoaffinity probe to tag and identify putative proteins that bind PCERA-1.

Original languageEnglish
Pages (from-to)3842-3845
Number of pages4
JournalChemical Communications
Volume53
Issue number27
DOIs
StatePublished - 1 Jan 2017

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry (all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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