Abstract
An experiment was conducted to show that imaging analysis that incubation of oligonucleotide-coated 15 nm (in diameter) silver NPs (AgNPs) with poly(dG)-poly(dC) DNA yields uniform DNA-based molecules whose length is shorter by one-third and the height is larger by about one-third than that of the parent DNA. Incubation of poly(dG)-poly(dC) DNA with 15 nm spherical AgNPs coated with (dA)10 , an oligonucleotide composed of ten deoxyadenosines, leads to noticeable changes in morphology of the dsDNA, measured by AFM. It is clearly seen that DNA-based molecules obtained by the incubation are smooth, uniform, less wavy, and more rigid as compared to the parent DNA. The analysis reveals the height increase, as well as a clear height-length correlation within each one of the two types of molecules. Co-deposition enables a true comparison between both molecule populations, since their morphological features are not scan-dependent and attained under the same measuring conditions
Original language | English |
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Pages (from-to) | 4839-4844 |
Number of pages | 6 |
Journal | Advanced Materials |
Volume | 28 |
Issue number | 24 |
DOIs | |
State | Published - 1 Jun 2016 |
Externally published | Yes |
Keywords
- DNA nanostructures
- DNA nanotechnology
- DNA-metallization
- molecular electronics
- poly(dG)-poly(dC)
- silver nanoparticles
ASJC Scopus subject areas
- General Materials Science
- Mechanics of Materials
- Mechanical Engineering