Synthesis, characterization and protein binding properties of supported dendrons

Olga Iliashevsky, Liron Amir, Robert Glaser, Robert S. Marks, N. Gabriel Lemcoff

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Novel benzylether type aldehyde and acetal terminated dendrons were synthesized and attached to a silica gel support; a linear spacer was also introduced as a control material. The supported dendritic compounds were mainly characterized by solid state 13C CPMAS NMR, elemental analysis and X-ray photoelectron spectroscopy (XPS) and the presence of free aldehydes was determined by the purpald test. Bovine serum albumin (BSA) protein was coupled to the dendronized support by imine bond formation, followed by irreversible reduction of the carbon-nitrogen double bond. A significant positive dendritic effect was observed on the antibody binding capacity of immobilised BSA as measured by fluorescence immunoassay (FIA).

Original languageEnglish
Pages (from-to)6616-6622
Number of pages7
JournalJournal of Materials Chemistry
Issue number36
StatePublished - 14 Sep 2009

ASJC Scopus subject areas

  • General Chemistry
  • Materials Chemistry


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