Synthesis of α-silylcarboxylic acids

Alex V. Shtelman, James Y. Becker

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


New α-silylacetic acids have been prepared following a general and convenient procedure of a one-pot reaction between trimethylsilylacetate and different chlorosilanes. New derivatives of diphenyl(methyl)silylacetic acid were prepared by a direct alkylation of its dianion with benzyl-, allyl-, and alkyl halides and trimethylchlorogermane to afford new α-silylcarboxylic acids.

Original languageEnglish
Pages (from-to)1135-1141
Number of pages7
Issue number6
StatePublished - 11 Feb 2011


  • Alkylation
  • Chlorosilanes
  • α, α′-Disilyldicarboxylic acids
  • α-Silylacetic acid dianion
  • α-Silylcarboxylic acids

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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