Synthesis of 1,3,4-thiadiazole derivatives by the reaction of thiosemicarbazide or its 1- or 4-substituted derivatives with some 1-bromo-2-acylacetylenes

A. S. Nakhmanovich, T. E. Glotova, T. N. Komarova, M. V. Sigalov, L. S. Romanenko

Research output: Contribution to journalArticlepeer-review

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Abstract

The reaction of thiosemicarbazide, 4-methyl-, 4-phenyl-, or 1-phenylthiosemicarbazides with 1-bromo-2-benzoyl(thenoyl-2)acetylenes in acetonitrile or glacial acetic acid yielded 2-acylmethylene- and 2-acylmethyl-5-amino-1,3,4-thiadiazoles. Heating of the latter in alcohol or aqueous alcohol gave the free bases.

Original languageEnglish
Pages (from-to)1186-1188
Number of pages3
JournalChemistry of Heterocyclic Compounds
Volume26
Issue number10
DOIs
StatePublished - 1 Oct 1990
Externally publishedYes

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