Abstract
Asmarines are marine alkaloids, with a unique tetrahydro[1,4]diazepino-[1,2,3-g,h]purine (THDAP) structure and interesting biological properties. Three synthetic approaches were employed for the preparation of the THDAP system. Several N-9, of the purine, protecting groups were investigated. 15N-Chemical shifts measured from 15NH HMBC experiments for several compounds, that demonstrate the influence of various structural features on the 15N-resonances are reported.
Original language | English |
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Pages (from-to) | 6493-6501 |
Number of pages | 9 |
Journal | Tetrahedron |
Volume | 59 |
Issue number | 34 |
DOIs | |
State | Published - 18 Aug 2003 |
Externally published | Yes |
Keywords
- Asmarine
- Diazepinopurine
- Mitsunobu reaction
- N resonances
- NH HMBC
- Purine
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry