The synthesis of a backbone bicyclic nonapeptide that mimics the binding site of bovine pancreatic trypsin inhibitor (BPTI) is described. The BPTI mimetic, which contains cis-thioproline replacing Cys38 of the protein, inhibits trypsin with a Ki of 76 μM.
- Backbone cyclic peptides
- Bovine pancreatic trypsin inhibitor
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