Synthesis of a bicyclic BPTI mimetic containing 4-thioproline replacing Cys38

Ron Kasher, Gal Bitan, Christeen Halloun, Chaim Gilon

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The synthesis of a backbone bicyclic nonapeptide that mimics the binding site of bovine pancreatic trypsin inhibitor (BPTI) is described. The BPTI mimetic, which contains cis-thioproline replacing Cys38 of the protein, inhibits trypsin with a Ki of 76 μM.

Original languageEnglish
Pages (from-to)101-103
Number of pages3
JournalLetters in Peptide Science
Volume5
Issue number2-3
DOIs
StatePublished - 1 Jan 1998
Externally publishedYes

Keywords

  • 4-thioproline
  • BPTI
  • Backbone cyclic peptides
  • Bovine pancreatic trypsin inhibitor
  • Peptidomimetic
  • Proteinomimetic

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