Synthesis of antibodies against measles virus and myelin by in vitro stimulated B-cells derived from patients with subacute sclerosing panencephalitis

Itzhak Wirguin; Michael Steinitz; Camille Sicsic; Oded Abramsky; Talma Brenner

doi:10.1016/0165-2478(93)90118-L

Synthesis of antibodies against measles virus and myelin by in vitro stimulated B-cells derived from patients with subacute sclerosing panencephalitis

Itzhak Wirguin
, Michael Steinitz
, Camille Sicsic
, Oded Abramsky
, Talma Brenner

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Subacute sclerosing panencephalitis (SSPE) patients carry persistent measles virus infection in the brain. Furthermore, the blood lymphocytes contain viral RNA. Lymphocytes derived from 6 SSPE patients were stimulated with Epstein-Barr virus (EBV). Production of antibodies against measles virus of the IgG isotype was detected in the supernatants of cell cultures of all patients, regardless of the disease's activity, duration or interferon therapy. In contrast, only some of these cell cultures also produced antibodies against myelin.

Original language	English
Pages (from-to)	55-58
Number of pages	4
Journal	Immunology Letters
Volume	38
Issue number	1
DOIs	https://doi.org/10.1016/0165-2478(93)90118-L
State	Published - 1 Jan 1993
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anti-measles virus antibody
Epstein-Barr virus-stimulated B-cell
Galactocerebroside
Myelin basic protein
Subacute sclerosing panencephalitis

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/0165-2478(93)90118-L

Cite this

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title = "Synthesis of antibodies against measles virus and myelin by in vitro stimulated B-cells derived from patients with subacute sclerosing panencephalitis",

abstract = "Subacute sclerosing panencephalitis (SSPE) patients carry persistent measles virus infection in the brain. Furthermore, the blood lymphocytes contain viral RNA. Lymphocytes derived from 6 SSPE patients were stimulated with Epstein-Barr virus (EBV). Production of antibodies against measles virus of the IgG isotype was detected in the supernatants of cell cultures of all patients, regardless of the disease's activity, duration or interferon therapy. In contrast, only some of these cell cultures also produced antibodies against myelin.",

keywords = "Anti-measles virus antibody, Epstein-Barr virus-stimulated B-cell, Galactocerebroside, Myelin basic protein, Subacute sclerosing panencephalitis",

author = "Itzhak Wirguin and Michael Steinitz and Camille Sicsic and Oded Abramsky and Talma Brenner",

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doi = "10.1016/0165-2478(93)90118-L",

language = "English",

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T1 - Synthesis of antibodies against measles virus and myelin by in vitro stimulated B-cells derived from patients with subacute sclerosing panencephalitis

AU - Wirguin, Itzhak

AU - Steinitz, Michael

AU - Sicsic, Camille

AU - Abramsky, Oded

AU - Brenner, Talma

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Subacute sclerosing panencephalitis (SSPE) patients carry persistent measles virus infection in the brain. Furthermore, the blood lymphocytes contain viral RNA. Lymphocytes derived from 6 SSPE patients were stimulated with Epstein-Barr virus (EBV). Production of antibodies against measles virus of the IgG isotype was detected in the supernatants of cell cultures of all patients, regardless of the disease's activity, duration or interferon therapy. In contrast, only some of these cell cultures also produced antibodies against myelin.

AB - Subacute sclerosing panencephalitis (SSPE) patients carry persistent measles virus infection in the brain. Furthermore, the blood lymphocytes contain viral RNA. Lymphocytes derived from 6 SSPE patients were stimulated with Epstein-Barr virus (EBV). Production of antibodies against measles virus of the IgG isotype was detected in the supernatants of cell cultures of all patients, regardless of the disease's activity, duration or interferon therapy. In contrast, only some of these cell cultures also produced antibodies against myelin.

KW - Anti-measles virus antibody

KW - Epstein-Barr virus-stimulated B-cell

KW - Galactocerebroside

KW - Myelin basic protein

KW - Subacute sclerosing panencephalitis

UR - https://www.scopus.com/pages/publications/0027428108

U2 - 10.1016/0165-2478(93)90118-L

DO - 10.1016/0165-2478(93)90118-L

M3 - Article

C2 - 7507883

AN - SCOPUS:0027428108

SN - 0165-2478

VL - 38

SP - 55

EP - 58

JO - Immunology Letters

JF - Immunology Letters

IS - 1

ER -

Synthesis of antibodies against measles virus and myelin by in vitro stimulated B-cells derived from patients with subacute sclerosing panencephalitis

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

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