Abstract
Biaryl-bridged cyclic peptides comprise an intriguing class of structurally diverse natural products with significant biological activity. Especially noteworthy are the antibiotics arylomycin and its synthetic analogue G0775, which exhibits potent activity against Gram-negative bacteria. Herein, we present a simple, flexible, and reliable strategy based on activating-group-assisted catalytic oxidative coupling for assembling biaryl-bridged cyclic peptides from natural amino acids. The synthetic approach was utilized for preparing a number of natural and unnatural biaryl-bridged cyclic peptides, including arylomycin/G0775 and RP 66453 cyclic cores.
Original language | English |
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Pages (from-to) | 4835-4839 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 59 |
Issue number | 12 |
DOIs | |
State | Published - 16 Mar 2020 |
Keywords
- C–H activation
- biaryls
- cyclic peptides
- dityrosine
- oxidative cross-coupling
ASJC Scopus subject areas
- Catalysis
- General Chemistry