Synthesis of heterocycles containing two cytosine or two guanine base- pairing sites. Novel tectons for self-assembly

Paul M. Petersen; Weiming Wu; Edward E. Fenlon; Sungho Kim; Steven C. Zimmerman

doi:10.1016/0968-0896(96)00103-4

Synthesis of heterocycles containing two cytosine or two guanine base- pairing sites. Novel tectons for self-assembly

Paul M. Petersen, Weiming Wu, Edward E. Fenlon, Sungho Kim, Steven C. Zimmerman

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The synthesis of 1 and 2 is described, as is the X-ray structure of 1. Tecton 1 contains two DAA hydrogen bonding sites (cytosine-like), while 2 contains two DDA sites (guanosine-like). Tectons 1 and 2 were designed to self-assemble into a helical superstructure. Self-recognition of 1 occurs in the solid state with a novel inclusion of dimethylacetamide solvent.

Original language	English
Pages (from-to)	1107-1112
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry
Volume	4
Issue number	7
DOIs	https://doi.org/10.1016/0968-0896(96)00103-4
State	Published - 1 Jan 1996
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/0968-0896(96)00103-4

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title = "Synthesis of heterocycles containing two cytosine or two guanine base- pairing sites. Novel tectons for self-assembly",

abstract = "The synthesis of 1 and 2 is described, as is the X-ray structure of 1. Tecton 1 contains two DAA hydrogen bonding sites (cytosine-like), while 2 contains two DDA sites (guanosine-like). Tectons 1 and 2 were designed to self-assemble into a helical superstructure. Self-recognition of 1 occurs in the solid state with a novel inclusion of dimethylacetamide solvent.",

author = "Petersen, {Paul M.} and Weiming Wu and Fenlon, {Edward E.} and Sungho Kim and Zimmerman, {Steven C.}",

note = "Funding Information: Funding from the National Institutes of Health (GM39783)i s gratefullya cknowledgeEd.. E. F. thanks the Universityo f Illinois Departmenotf Chemistryfo r graduate fellowship support. Scott R. Wilson is thankedfo r assistancwei th the X-ray analysis.",

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doi = "10.1016/0968-0896(96)00103-4",

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T1 - Synthesis of heterocycles containing two cytosine or two guanine base- pairing sites. Novel tectons for self-assembly

AU - Petersen, Paul M.

AU - Wu, Weiming

AU - Fenlon, Edward E.

AU - Kim, Sungho

AU - Zimmerman, Steven C.

N1 - Funding Information: Funding from the National Institutes of Health (GM39783)i s gratefullya cknowledgeEd.. E. F. thanks the Universityo f Illinois Departmenotf Chemistryfo r graduate fellowship support. Scott R. Wilson is thankedfo r assistancwei th the X-ray analysis.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - The synthesis of 1 and 2 is described, as is the X-ray structure of 1. Tecton 1 contains two DAA hydrogen bonding sites (cytosine-like), while 2 contains two DDA sites (guanosine-like). Tectons 1 and 2 were designed to self-assemble into a helical superstructure. Self-recognition of 1 occurs in the solid state with a novel inclusion of dimethylacetamide solvent.

AB - The synthesis of 1 and 2 is described, as is the X-ray structure of 1. Tecton 1 contains two DAA hydrogen bonding sites (cytosine-like), while 2 contains two DDA sites (guanosine-like). Tectons 1 and 2 were designed to self-assemble into a helical superstructure. Self-recognition of 1 occurs in the solid state with a novel inclusion of dimethylacetamide solvent.

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JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

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ER -

Synthesis of heterocycles containing two cytosine or two guanine base- pairing sites. Novel tectons for self-assembly

Abstract

ASJC Scopus subject areas

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