Synthesis of N-quinonyltaurines

S. Gorohovsky, G. Temtsin-Krayz, Shmuel Bittner

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Both 1,4-benzoquinones and 1,4-naphthoquinones were attached to the non-proteinogenic amino acid taurine to form N-quinonyl taurine derivatives. The products were formed via the direct Michael-like addition or by substitution of a good leaving group. An attempt to bridge the two moieties via an ureido spacer resulted in the formation of a bis-quinonylamino isocyanurate derivative. Preliminary MO calculations provided internal ground-state geometries and orbital coefficients of the HOMO levels in two representing taurine conjugates.

Original languageEnglish
Pages (from-to)281-287
Number of pages7
JournalAmino Acids
Issue number3
StatePublished - 1 Apr 2003


  • Amino acids
  • Isocyanates
  • Isocyanurate
  • Quinones
  • Taurine

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry


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