Synthesis of Polyfunctional Secondary Amines by the Reaction of Functionalized Organomagnesium Reagents with Tertiary Nitroalkanes

Vasudevan Dhayalan, Paul Knochel

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Addition of polyfunctionalized aryl, heteroaryl, and tertiary alkylmagnesium reagents to tertiary nitroalkanes at 25A"°C in tetrahydrofuran produces, after reductive workup with FeCl2 and NaBH4 in ethanol, the corresponding polyfunctional secondary amines in high yields.

Original languageEnglish
Article numberss-2015-t0367-op
Pages (from-to)3246-3256
Number of pages11
JournalSynthesis (Germany)
Volume47
Issue number20
DOIs
StatePublished - 16 Oct 2015
Externally publishedYes

Keywords

  • adamantane
  • amination reactions
  • nitroalkanes
  • organomagnesium reagents
  • secondary amines

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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