Synthesis of vernolamides containing tertiary amino groups from Vernonia galamensis oil and their biological activities

C. K. Mambo; P. M. Gitu; B. M. Bhatt; J. Chweya; S. Grinberg; D. Mills

Synthesis of vernolamides containing tertiary amino groups from Vernonia galamensis oil and their biological activities

C. K. Mambo, P. M. Gitu, B. M. Bhatt, J. Chweya, S. Grinberg, D. Mills

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6 Scopus citations

Abstract

The vernonia oil obtained by soxhlet and cold extractions from Vernonia galamensis seeds was reacted with 1-(2-aminoethyl)pyrrolidine, 4-(3-aminopropyl)-morpholine and 1-(3-aminopropyl)-2-pyrrolidinone (molar ratio 1:3) at 50̊C to obtain: N-2-(1-pyrrolidino)ethylvernolamide, N-3-(4-morpholino)propylvernolamide and N-3-[1-(2-oxopyrrol-idino)]propylvernolamide, respectively. The reactions were complete after 16-18 hours. The antimicrobial activities of the vernolamides were investigated against Staphylococcus aureus (gram-positive), Escherichia coli (gram-negative), Bacillus subtilis, Trichophyton mentagrophyte, Microsporum gypseumCandida albicans and Saccharomyces cerevisiae. The vernolamides exhibited both antibacterial and antifungal activities.

Original language	English
Pages (from-to)	121-128
Number of pages	8
Journal	Bulletin of the Chemical Society of Ethiopia
Volume	12
Issue number	2
State	Published - 1 Dec 1998

ASJC Scopus subject areas

General Chemistry

Cite this

@article{87892e3966fb48eab1bb4ac75d0bb674,

title = "Synthesis of vernolamides containing tertiary amino groups from Vernonia galamensis oil and their biological activities",

abstract = "The vernonia oil obtained by soxhlet and cold extractions from Vernonia galamensis seeds was reacted with 1-(2-aminoethyl)pyrrolidine, 4-(3-aminopropyl)-morpholine and 1-(3-aminopropyl)-2-pyrrolidinone (molar ratio 1:3) at 50̊C to obtain: N-2-(1-pyrrolidino)ethylvernolamide, N-3-(4-morpholino)propylvernolamide and N-3-[1-(2-oxopyrrol-idino)]propylvernolamide, respectively. The reactions were complete after 16-18 hours. The antimicrobial activities of the vernolamides were investigated against Staphylococcus aureus (gram-positive), Escherichia coli (gram-negative), Bacillus subtilis, Trichophyton mentagrophyte, Microsporum gypseumCandida albicans and Saccharomyces cerevisiae. The vernolamides exhibited both antibacterial and antifungal activities.",

author = "Mambo, {C. K.} and Gitu, {P. M.} and Bhatt, {B. M.} and J. Chweya and S. Grinberg and D. Mills",

year = "1998",

month = dec,

day = "1",

language = "English",

volume = "12",

pages = "121--128",

journal = "Bulletin of the Chemical Society of Ethiopia",

issn = "1011-3924",

publisher = "Chemical Society of Ethiopia",

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TY - JOUR

T1 - Synthesis of vernolamides containing tertiary amino groups from Vernonia galamensis oil and their biological activities

AU - Mambo, C. K.

AU - Gitu, P. M.

AU - Bhatt, B. M.

AU - Chweya, J.

AU - Grinberg, S.

AU - Mills, D.

PY - 1998/12/1

Y1 - 1998/12/1

N2 - The vernonia oil obtained by soxhlet and cold extractions from Vernonia galamensis seeds was reacted with 1-(2-aminoethyl)pyrrolidine, 4-(3-aminopropyl)-morpholine and 1-(3-aminopropyl)-2-pyrrolidinone (molar ratio 1:3) at 50̊C to obtain: N-2-(1-pyrrolidino)ethylvernolamide, N-3-(4-morpholino)propylvernolamide and N-3-[1-(2-oxopyrrol-idino)]propylvernolamide, respectively. The reactions were complete after 16-18 hours. The antimicrobial activities of the vernolamides were investigated against Staphylococcus aureus (gram-positive), Escherichia coli (gram-negative), Bacillus subtilis, Trichophyton mentagrophyte, Microsporum gypseumCandida albicans and Saccharomyces cerevisiae. The vernolamides exhibited both antibacterial and antifungal activities.

AB - The vernonia oil obtained by soxhlet and cold extractions from Vernonia galamensis seeds was reacted with 1-(2-aminoethyl)pyrrolidine, 4-(3-aminopropyl)-morpholine and 1-(3-aminopropyl)-2-pyrrolidinone (molar ratio 1:3) at 50̊C to obtain: N-2-(1-pyrrolidino)ethylvernolamide, N-3-(4-morpholino)propylvernolamide and N-3-[1-(2-oxopyrrol-idino)]propylvernolamide, respectively. The reactions were complete after 16-18 hours. The antimicrobial activities of the vernolamides were investigated against Staphylococcus aureus (gram-positive), Escherichia coli (gram-negative), Bacillus subtilis, Trichophyton mentagrophyte, Microsporum gypseumCandida albicans and Saccharomyces cerevisiae. The vernolamides exhibited both antibacterial and antifungal activities.

UR - http://www.scopus.com/inward/record.url?scp=3042999731&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:3042999731

SN - 1011-3924

VL - 12

SP - 121

EP - 128

JO - Bulletin of the Chemical Society of Ethiopia

JF - Bulletin of the Chemical Society of Ethiopia

IS - 2

ER -

Synthesis of vernolamides containing tertiary amino groups from Vernonia galamensis oil and their biological activities

Abstract

ASJC Scopus subject areas

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