The vernonia oil obtained by soxhlet and cold extractions from Vernonia galamensis seeds was reacted with 1-(2-aminoethyl)pyrrolidine, 4-(3-aminopropyl)-morpholine and 1-(3-aminopropyl)-2-pyrrolidinone (molar ratio 1:3) at 50̊C to obtain: N-2-(1-pyrrolidino)ethylvernolamide, N-3-(4-morpholino)propylvernolamide and N-3-[1-(2-oxopyrrol-idino)]propylvernolamide, respectively. The reactions were complete after 16-18 hours. The antimicrobial activities of the vernolamides were investigated against Staphylococcus aureus (gram-positive), Escherichia coli (gram-negative), Bacillus subtilis, Trichophyton mentagrophyte, Microsporum gypseumCandida albicans and Saccharomyces cerevisiae. The vernolamides exhibited both antibacterial and antifungal activities.
|Number of pages||8|
|Journal||Bulletin of the Chemical Society of Ethiopia|
|State||Published - 1 Dec 1998|
ASJC Scopus subject areas
- Chemistry (all)