Synthesis, X-ray structure, and hydrolytic chemistry of the highly potent antiviral polyniobotungstate A-α-[Si2Nb6W18O77]8-

Gyu Shik Kim; Huadong Zeng; Jeffrey T. Rhule; Ira A. Weinstock; Craig L. Hill

doi:10.1039/a903983j

Synthesis, X-ray structure, and hydrolytic chemistry of the highly potent antiviral polyniobotungstate A-α-[Si₂Nb₆W₁₈O₇₇]^8-

Gyu Shik Kim, Huadong Zeng, Jeffrey T. Rhule, Ira A. Weinstock, Craig L. Hill

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Potently antiviral polyniobotungstates have been structurally characterized; the dimer A-α-[Si₂Nb₆W₁₈O₇₇]^8- cleaves cleanly to the monomer A-α-[SiNb₃W₉O₄₀]^7- within 1 min in aqueous solution buffered at physiological (neutral) pH establishing that the monomer and not the dimer is pharmacologically relevant.

Original language	English
Pages (from-to)	1651-1652
Number of pages	2
Journal	Chemical Communications
Issue number	17
DOIs	https://doi.org/10.1039/a903983j
State	Published - 7 Sep 1999
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Synthesis, X-ray structure, and hydrolytic chemistry of the highly potent antiviral polyniobotungstate A-α-[Si2Nb6W18O77]8-",

abstract = "Potently antiviral polyniobotungstates have been structurally characterized; the dimer A-α-[Si2Nb6W18O77]8- cleaves cleanly to the monomer A-α-[SiNb3W9O40]7- within 1 min in aqueous solution buffered at physiological (neutral) pH establishing that the monomer and not the dimer is pharmacologically relevant.",

author = "Kim, {Gyu Shik} and Huadong Zeng and Rhule, {Jeffrey T.} and Weinstock, {Ira A.} and Hill, {Craig L.}",

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AU - Kim, Gyu Shik

AU - Zeng, Huadong

AU - Rhule, Jeffrey T.

AU - Weinstock, Ira A.

AU - Hill, Craig L.

PY - 1999/9/7

Y1 - 1999/9/7

N2 - Potently antiviral polyniobotungstates have been structurally characterized; the dimer A-α-[Si2Nb6W18O77]8- cleaves cleanly to the monomer A-α-[SiNb3W9O40]7- within 1 min in aqueous solution buffered at physiological (neutral) pH establishing that the monomer and not the dimer is pharmacologically relevant.

AB - Potently antiviral polyniobotungstates have been structurally characterized; the dimer A-α-[Si2Nb6W18O77]8- cleaves cleanly to the monomer A-α-[SiNb3W9O40]7- within 1 min in aqueous solution buffered at physiological (neutral) pH establishing that the monomer and not the dimer is pharmacologically relevant.

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Synthesis, X-ray structure, and hydrolytic chemistry of the highly potent antiviral polyniobotungstate A-α-[Si₂Nb₆W₁₈O₇₇]^8-

Abstract

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