Synthesis, X-ray structure, and hydrolytic chemistry of the highly potent antiviral polyniobotungstate A-α-[Si2Nb6W18O77]8-

Gyu Shik Kim; Huadong Zeng; Jeffrey T. Rhule; Ira A. Weinstock; Craig L. Hill

doi:10.1039/a903983j

Synthesis, X-ray structure, and hydrolytic chemistry of the highly potent antiviral polyniobotungstate A-α-[Si₂Nb₆W₁₈O₇₇]^8-

Gyu Shik Kim, Huadong Zeng, Jeffrey T. Rhule, Ira A. Weinstock, Craig L. Hill

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Potently antiviral polyniobotungstates have been structurally characterized; the dimer A-α-[Si₂Nb₆W₁₈O₇₇]^8- cleaves cleanly to the monomer A-α-[SiNb₃W₉O₄₀]^7- within 1 min in aqueous solution buffered at physiological (neutral) pH establishing that the monomer and not the dimer is pharmacologically relevant.

Original language	English
Pages (from-to)	1651-1652
Number of pages	2
Journal	Chemical Communications
Issue number	17
DOIs	https://doi.org/10.1039/a903983j
State	Published - 7 Sep 1999
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/a903983j

Cite this

@article{e64156d789794b61ac9458432f45a7ab,

title = "Synthesis, X-ray structure, and hydrolytic chemistry of the highly potent antiviral polyniobotungstate A-α-[Si2Nb6W18O77]8-",

abstract = "Potently antiviral polyniobotungstates have been structurally characterized; the dimer A-α-[Si2Nb6W18O77]8- cleaves cleanly to the monomer A-α-[SiNb3W9O40]7- within 1 min in aqueous solution buffered at physiological (neutral) pH establishing that the monomer and not the dimer is pharmacologically relevant.",

author = "Kim, \{Gyu Shik\} and Huadong Zeng and Rhule, \{Jeffrey T.\} and Weinstock, \{Ira A.\} and Hill, \{Craig L.\}",

year = "1999",

month = sep,

day = "7",

doi = "10.1039/a903983j",

language = "English",

pages = "1651--1652",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "17",

}

TY - JOUR

T1 - Synthesis, X-ray structure, and hydrolytic chemistry of the highly potent antiviral polyniobotungstate A-α-[Si2Nb6W18O77]8-

AU - Kim, Gyu Shik

AU - Zeng, Huadong

AU - Rhule, Jeffrey T.

AU - Weinstock, Ira A.

AU - Hill, Craig L.

PY - 1999/9/7

Y1 - 1999/9/7

N2 - Potently antiviral polyniobotungstates have been structurally characterized; the dimer A-α-[Si2Nb6W18O77]8- cleaves cleanly to the monomer A-α-[SiNb3W9O40]7- within 1 min in aqueous solution buffered at physiological (neutral) pH establishing that the monomer and not the dimer is pharmacologically relevant.

AB - Potently antiviral polyniobotungstates have been structurally characterized; the dimer A-α-[Si2Nb6W18O77]8- cleaves cleanly to the monomer A-α-[SiNb3W9O40]7- within 1 min in aqueous solution buffered at physiological (neutral) pH establishing that the monomer and not the dimer is pharmacologically relevant.

UR - https://www.scopus.com/pages/publications/0033533424

U2 - 10.1039/a903983j

DO - 10.1039/a903983j

M3 - Article

AN - SCOPUS:0033533424

SN - 1359-7345

SP - 1651

EP - 1652

JO - Chemical Communications

JF - Chemical Communications

IS - 17

ER -

Synthesis, X-ray structure, and hydrolytic chemistry of the highly potent antiviral polyniobotungstate A-α-[Si₂Nb₆W₁₈O₇₇]^8-

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this