Systematic evaluation of a few proline derivatives as catalysts for a direct aldol reaction

Revannath L. Sutar, Navalkishore N. Joshi

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

A series of pyrrolidine derivatives were prepared and examined as catalysts for an aldol reaction. Structural variations in these molecules involved altering the sterics at the α-position, the position of the carbonyl group, and the acidities of the hydrogen bonding sites. The effect of these factors on catalytic activity and enantioselectivity was studied. The experimental results revealed that additional sterics at the α-position were detrimental. However, no correlation was found between the catalytic activity and N-H acidity.

Original languageEnglish
Pages (from-to)43-49
Number of pages7
JournalTetrahedron Asymmetry
Volume24
Issue number1
DOIs
StatePublished - 15 Jan 2013
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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