T-cell autoimmunity in type 1 diabetes mellitus

Ohad S. Birk, Irun R. Cohen

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Insulin dependent diabetes mellitus is a T-cell mediated autoimmune disease. Several β-cell antigens, mostly non-tissue-specific, have been implicated in the disease process. The antigens and the autoimmune T cells exist in healthy individuals, as do many of the genes required for the development of diabetes. The question, then, is why and how exposure to undefined environmental agents activates an existing autoimmune potential and directs it to damage the β cells.

Original languageEnglish
Pages (from-to)903-909
Number of pages7
JournalCurrent Opinion in Immunology
Volume5
Issue number6
DOIs
StatePublished - 1 Jan 1993
Externally publishedYes

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