Tadpole-shaped β-cyclodextrin-tagged poly(N-vinylpyrrolidone): Synthesis, characterization and studies of its complexation with phenolphthalein and anti tumor activities

Niraj Kumar Vishwakarma; Vijay Kumar Patel; Sumit Kumar Hira; K. Ramesh; Prateek Srivastava; Kheyanath Mitra; Shikha Singh; Dipankar Chattopadhyay; Pralay Maiti; Nira Misra; Partha Pratim Manna; Biswajit Ray

doi:10.1039/c4ra15359f

Tadpole-shaped β-cyclodextrin-tagged poly(N-vinylpyrrolidone): Synthesis, characterization and studies of its complexation with phenolphthalein and anti tumor activities

Niraj Kumar Vishwakarma, Vijay Kumar Patel, Sumit Kumar Hira, K. Ramesh, Prateek Srivastava, Kheyanath Mitra, Shikha Singh, Dipankar Chattopadhyay, Pralay Maiti, Nira Misra, Partha Pratim Manna, Biswajit Ray

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Tadpole-shaped β-cyclodextrin-tagged poly(N-vinylpyrrolidone) (β-CD-PNVP) has been synthesised via the click reaction of alkyne-terminated PNVP and azide-functionalized β-CD. The formed polymer is characterized by ¹H NMR, FTIR, and TGA study. The complexing ability of such a polymer with phenolphthalein is considerably lower with respect to that with β-CD alone. Doxorubicin (DOX)-loaded β-CD-PNVP (DOX-β-CD-PNVP) exhibits higher tumoricidal activity against a panel of tumor cell lines derived from sarcoma (U2-OS) and carcinomas (MCF-7 and HEPG2), causing significant lysis of tumor cells compared to free DOX. The formulation also demonstrates significantly higher uptake by the tumor cells and enhances apoptosis compared to free DOX.

Original language	English
Pages (from-to)	15547-15558
Number of pages	12
Journal	RSC Advances
Volume	5
Issue number	20
DOIs	https://doi.org/10.1039/c4ra15359f
State	Published - 1 Jan 2015
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c4ra15359f

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Vishwakarma, N. K., Patel, V. K., Hira, S. K., Ramesh, K., Srivastava, P., Mitra, K., Singh, S., Chattopadhyay, D., Maiti, P., Misra, N., Manna, P. P., & Ray, B. (2015). Tadpole-shaped β-cyclodextrin-tagged poly(N-vinylpyrrolidone): Synthesis, characterization and studies of its complexation with phenolphthalein and anti tumor activities. RSC Advances, 5(20), 15547-15558. https://doi.org/10.1039/c4ra15359f

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title = "Tadpole-shaped β-cyclodextrin-tagged poly(N-vinylpyrrolidone): Synthesis, characterization and studies of its complexation with phenolphthalein and anti tumor activities",

abstract = "Tadpole-shaped β-cyclodextrin-tagged poly(N-vinylpyrrolidone) (β-CD-PNVP) has been synthesised via the click reaction of alkyne-terminated PNVP and azide-functionalized β-CD. The formed polymer is characterized by 1H NMR, FTIR, and TGA study. The complexing ability of such a polymer with phenolphthalein is considerably lower with respect to that with β-CD alone. Doxorubicin (DOX)-loaded β-CD-PNVP (DOX-β-CD-PNVP) exhibits higher tumoricidal activity against a panel of tumor cell lines derived from sarcoma (U2-OS) and carcinomas (MCF-7 and HEPG2), causing significant lysis of tumor cells compared to free DOX. The formulation also demonstrates significantly higher uptake by the tumor cells and enhances apoptosis compared to free DOX.",

author = "Vishwakarma, \{Niraj Kumar\} and Patel, \{Vijay Kumar\} and Hira, \{Sumit Kumar\} and K. Ramesh and Prateek Srivastava and Kheyanath Mitra and Shikha Singh and Dipankar Chattopadhyay and Pralay Maiti and Nira Misra and Manna, \{Partha Pratim\} and Biswajit Ray",

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year = "2015",

month = jan,

day = "1",

doi = "10.1039/c4ra15359f",

language = "English",

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Vishwakarma, NK, Patel, VK, Hira, SK, Ramesh, K, Srivastava, P, Mitra, K, Singh, S, Chattopadhyay, D, Maiti, P, Misra, N, Manna, PP & Ray, B 2015, 'Tadpole-shaped β-cyclodextrin-tagged poly(N-vinylpyrrolidone): Synthesis, characterization and studies of its complexation with phenolphthalein and anti tumor activities', RSC Advances, vol. 5, no. 20, pp. 15547-15558. https://doi.org/10.1039/c4ra15359f

Tadpole-shaped β-cyclodextrin-tagged poly(N-vinylpyrrolidone): Synthesis, characterization and studies of its complexation with phenolphthalein and anti tumor activities. / Vishwakarma, Niraj Kumar; Patel, Vijay Kumar; Hira, Sumit Kumar et al.
In: RSC Advances, Vol. 5, No. 20, 01.01.2015, p. 15547-15558.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Tadpole-shaped β-cyclodextrin-tagged poly(N-vinylpyrrolidone)

T2 - Synthesis, characterization and studies of its complexation with phenolphthalein and anti tumor activities

AU - Vishwakarma, Niraj Kumar

AU - Patel, Vijay Kumar

AU - Hira, Sumit Kumar

AU - Ramesh, K.

AU - Srivastava, Prateek

AU - Mitra, Kheyanath

AU - Singh, Shikha

AU - Chattopadhyay, Dipankar

AU - Maiti, Pralay

AU - Misra, Nira

AU - Manna, Partha Pratim

AU - Ray, Biswajit

PY - 2015/1/1

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AB - Tadpole-shaped β-cyclodextrin-tagged poly(N-vinylpyrrolidone) (β-CD-PNVP) has been synthesised via the click reaction of alkyne-terminated PNVP and azide-functionalized β-CD. The formed polymer is characterized by 1H NMR, FTIR, and TGA study. The complexing ability of such a polymer with phenolphthalein is considerably lower with respect to that with β-CD alone. Doxorubicin (DOX)-loaded β-CD-PNVP (DOX-β-CD-PNVP) exhibits higher tumoricidal activity against a panel of tumor cell lines derived from sarcoma (U2-OS) and carcinomas (MCF-7 and HEPG2), causing significant lysis of tumor cells compared to free DOX. The formulation also demonstrates significantly higher uptake by the tumor cells and enhances apoptosis compared to free DOX.

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DO - 10.1039/c4ra15359f

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SN - 2046-2069

VL - 5

SP - 15547

EP - 15558

JO - RSC Advances

JF - RSC Advances

IS - 20

ER -

Tadpole-shaped β-cyclodextrin-tagged poly(N-vinylpyrrolidone): Synthesis, characterization and studies of its complexation with phenolphthalein and anti tumor activities

Abstract

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