Tamoxifen therapy for the management of pubertal gynecomastia: A systematic review

Oren Lapid, Jan J. Van Wingerden, Leon Perlemuter

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations


Objective: A systematic review to assess the efficacy of tamoxifen in the management of idiopathic pubertal gynecomastia. Data sources: Searches were conducted using the databases of Medline (search engine PubMed) and Web of Science®. Study selection: Studies reporting the use of Tamoxifen for the treatment of gynecomastia in adolescents. Outcome measure: Resolution of gynecomastia. Results: A total of 164 publications were found; 59 were selected for retrieval and six were included in the review. There were no randomized controlled studies; the studies found have methodological flaws but show promising results. No clinical side-effects were reported or observed. Conclusion: Tamoxifen may be effective for the treatment of pubertal gynecomastia, and it seems safe to use. Randomized controlled studies are necessary to confirm this indication.

Original languageEnglish
Pages (from-to)803-807
Number of pages5
JournalJournal of Pediatric Endocrinology and Metabolism
Issue number9-10
StatePublished - 1 Oct 2013
Externally publishedYes


  • Adolescent
  • Breast
  • Gynecomastia
  • Male
  • Puberty
  • Tamoxifen

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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