Abstract
Objective: A systematic review to assess the efficacy of tamoxifen in the management of idiopathic pubertal gynecomastia. Data sources: Searches were conducted using the databases of Medline (search engine PubMed) and Web of Science®. Study selection: Studies reporting the use of Tamoxifen for the treatment of gynecomastia in adolescents. Outcome measure: Resolution of gynecomastia. Results: A total of 164 publications were found; 59 were selected for retrieval and six were included in the review. There were no randomized controlled studies; the studies found have methodological flaws but show promising results. No clinical side-effects were reported or observed. Conclusion: Tamoxifen may be effective for the treatment of pubertal gynecomastia, and it seems safe to use. Randomized controlled studies are necessary to confirm this indication.
Original language | English |
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Pages (from-to) | 803-807 |
Number of pages | 5 |
Journal | Journal of Pediatric Endocrinology and Metabolism |
Volume | 26 |
Issue number | 9-10 |
DOIs | |
State | Published - 1 Oct 2013 |
Externally published | Yes |
Keywords
- Adolescent
- Breast
- Gynecomastia
- Male
- Puberty
- Tamoxifen
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Endocrinology, Diabetes and Metabolism
- Endocrinology