Tandem one pot synthesis of 1,5-benzodiazocine-2-one by isocyanide based Ugi multicomponent reaction

Goutam Kulsi, Abhijit Ghorai, Partha Chattopadhyay

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

We have developed an efficient one-pot, two-step reaction protocol for the synthesis of eight-membered 1,5-benzodiazocine-2-ones by Ugi four-center three-component coupling reaction (U-4C-3CR) and subsequent reductive cyclization using Fe/NH 4Cl in protic solvent.

Original languageEnglish
Pages (from-to)3619-3622
Number of pages4
JournalTetrahedron Letters
Volume53
Issue number28
DOIs
StatePublished - 11 Jul 2012
Externally publishedYes

Keywords

  • Benzodiazocine
  • Fe/NH Cl
  • Heterocycles
  • IMCR
  • Ugi reaction

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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