Tandem one pot synthesis of 1,5-benzodiazocine-2-one by isocyanide based Ugi multicomponent reaction

Goutam Kulsi; Abhijit Ghorai; Partha Chattopadhyay

doi:10.1016/j.tetlet.2012.05.013

Tandem one pot synthesis of 1,5-benzodiazocine-2-one by isocyanide based Ugi multicomponent reaction

Goutam Kulsi, Abhijit Ghorai, Partha Chattopadhyay

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We have developed an efficient one-pot, two-step reaction protocol for the synthesis of eight-membered 1,5-benzodiazocine-2-ones by Ugi four-center three-component coupling reaction (U-4C-3CR) and subsequent reductive cyclization using Fe/NH ₄Cl in protic solvent.

Original language	English
Pages (from-to)	3619-3622
Number of pages	4
Journal	Tetrahedron Letters
Volume	53
Issue number	28
DOIs	https://doi.org/10.1016/j.tetlet.2012.05.013
State	Published - 11 Jul 2012
Externally published	Yes

Keywords

Benzodiazocine
Fe/NH Cl
Heterocycles
IMCR
Ugi reaction

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tetlet.2012.05.013

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title = "Tandem one pot synthesis of 1,5-benzodiazocine-2-one by isocyanide based Ugi multicomponent reaction",

abstract = "We have developed an efficient one-pot, two-step reaction protocol for the synthesis of eight-membered 1,5-benzodiazocine-2-ones by Ugi four-center three-component coupling reaction (U-4C-3CR) and subsequent reductive cyclization using Fe/NH 4Cl in protic solvent.",

keywords = "Benzodiazocine, Fe/NH Cl, Heterocycles, IMCR, Ugi reaction",

author = "Goutam Kulsi and Abhijit Ghorai and Partha Chattopadhyay",

note = "Funding Information: We thank the CSIR (New Delhi) for funding research project (NWP 0005) and providing research fellowship to G.K. and A.G. We thank Dr. B. Achari, formerly of IICB, and Professor B. Dinda of Tripura Central University for their helpful suggestion and support. ",

year = "2012",

month = jul,

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doi = "10.1016/j.tetlet.2012.05.013",

language = "English",

volume = "53",

pages = "3619--3622",

journal = "Tetrahedron Letters",

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TY - JOUR

T1 - Tandem one pot synthesis of 1,5-benzodiazocine-2-one by isocyanide based Ugi multicomponent reaction

AU - Kulsi, Goutam

AU - Ghorai, Abhijit

AU - Chattopadhyay, Partha

N1 - Funding Information: We thank the CSIR (New Delhi) for funding research project (NWP 0005) and providing research fellowship to G.K. and A.G. We thank Dr. B. Achari, formerly of IICB, and Professor B. Dinda of Tripura Central University for their helpful suggestion and support.

PY - 2012/7/11

Y1 - 2012/7/11

N2 - We have developed an efficient one-pot, two-step reaction protocol for the synthesis of eight-membered 1,5-benzodiazocine-2-ones by Ugi four-center three-component coupling reaction (U-4C-3CR) and subsequent reductive cyclization using Fe/NH 4Cl in protic solvent.

AB - We have developed an efficient one-pot, two-step reaction protocol for the synthesis of eight-membered 1,5-benzodiazocine-2-ones by Ugi four-center three-component coupling reaction (U-4C-3CR) and subsequent reductive cyclization using Fe/NH 4Cl in protic solvent.

KW - Benzodiazocine

KW - Fe/NH Cl

KW - Heterocycles

KW - IMCR

KW - Ugi reaction

UR - http://www.scopus.com/inward/record.url?scp=84861975831&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2012.05.013

DO - 10.1016/j.tetlet.2012.05.013

M3 - Article

AN - SCOPUS:84861975831

SN - 0040-4039

VL - 53

SP - 3619

EP - 3622

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 28

ER -

Tandem one pot synthesis of 1,5-benzodiazocine-2-one by isocyanide based Ugi multicomponent reaction

Abstract

Keywords

ASJC Scopus subject areas

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