Tardive dyskinesia (syndrome): Current concept and modern approaches to its management

Paul P. Lerner, Chanoch Miodownik, Vladimir Lerner

Research output: Contribution to journalReview articlepeer-review

79 Scopus citations


Tardive dyskinesia is a serious, disabling and potentially permanent, neurological hyperkinetic movement disorder that occurs after months or years of taking psychotropic drugs. The pathophysiology of tardive dyskinesia is complex, multifactorial and still not fully understood. A number of drugs were tried for the management of this motor disturbance, yet until now no effective and standard treatment has been found. It is very disappointing to realize that the introduction of antipsychotics from the second generation has not significantly decreased the prevalence and incidence of tardive dyskinesia. Therefore, the management of this motor disturbance remains an actual topic as well as a challenge for clinicians. This review summarizes recent relevant publications concerning the treatment of tardive dyskinesia.

Original languageEnglish
Pages (from-to)321-334
Number of pages14
JournalPsychiatry and Clinical Neurosciences
Issue number6
StatePublished - 1 Jun 2015


  • first-generation agents
  • management
  • schizophrenia
  • second-generation agents
  • tardive dyskinesia

ASJC Scopus subject areas

  • General Neuroscience
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health


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