Targeting LDL Cholesterol: Beyond Absolute Goals Toward Personalized Risk

Morton Leibowitz, Chandra Cohen-Stavi, Sanjay Basu, Ran D. Balicer

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Purpose of Review: The aim of this study was to review and assess the evidence for low-density lipoprotein cholesterol (LDL-C) treatment goals as presented in current guidelines for primary and secondary prevention of cardiovascular disease. Recent Findings: Different sets of guidelines and clinical studies for secondary prevention have centered on lower absolute LDL-C targets [<70 mg/dL (<1.8 mmol/L)], greater percent reductions of LDL-C (≥50%), or more intense treatment to achieve greater reductions in cardiovascular risk. Population-based risk models serve as the basis for statin initiation in primary prevention. Reviews of current population risk models for primary prevention show moderate ability to discriminate [with c-statistics ranging from 0.67 to 0.77 (95% CIs from 0.62 to 0.83) for men and women] with poor calibration and overestimation of risk. Summary: Individual clinical trial data are not compelling to support specific LDL-C targets and percent reductions in secondary prevention. Increasing utilization of electronic health records and data analytics will enable the development of individualized treatment goals in both primary and secondary prevention.

Original languageEnglish
Article number52
JournalCurrent Cardiology Reports
Issue number6
StatePublished - 1 Jun 2017
Externally publishedYes


  • Cardiovascular disease prevention
  • Low-density lipoprotein cholesterol
  • Major adverse cardiac events
  • Statins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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