Technical aspects of transcervical chorionic villus sampling

Nelson B. Isada, Mark P. Johnson, Peter G. Pryde, Mordechai Hallak, Mark I. Evans

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Following the 1990 FDA approval of the T rophocan® catheter for use in transcervical chorionic villus sampling (CVS), an increasing number of US physicians have begun offering the procedure. To obtain privileges to perform CVS, some states such as California have enacted legislation requiring the performance of a certain number of CVS procedures in pregnancies in which the patient has already chosen first-trimester abortion. This practice is not universally feasible for legal, logistic, or financial reasons. We describe our approach to training in a busy reproductive genetics service. The physician initially trains by performing amniocentesis to optimize skills in ultrasound-directed needle guidance and placement. During this initial period, he or she also assists in performing transabdominal CVS procedures. The initial transcervical CVS cases should be performed in those situations requiring minimal catheter manipulation, or in those individuals undergoing CVS in the setting of spontaneous abortion. Cases of increasing difficulty should only be performed as skill and familiarity increase. For a physician already skilled and experienced in ultrasound-guided invasive procedures, sequential periods of observation at a busy center allows him or her to become familiar with the common pitfalls in performing transcervical CVS, and thus avoid them. Using this approach, we have performed over 5,000 CVS procedures and trained 6 reproductive genetics fellows in transcervical CVS.

Original languageEnglish
Pages (from-to)19-28
Number of pages10
JournalFetal Diagnosis and Therapy
Issue number1
StatePublished - 1 Jan 1994
Externally publishedYes


  • Chorionic villus sampling
  • Prenatal diagnosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Radiology Nuclear Medicine and imaging
  • Obstetrics and Gynecology


Dive into the research topics of 'Technical aspects of transcervical chorionic villus sampling'. Together they form a unique fingerprint.

Cite this