Technical Pitfall in 68Ga-Prostate Specific Membrane Antigen Imaging: Altered Biodistribution Caused by Free 68Ga-Citrate Due to Radiolysis Showing Increased Vascular Activity

Nir Hod, Reut Anconina, Daniel Levin, Dina Ezroh Kazap, Sophie Lantsberg

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

As with any new molecular imaging modality, accurate characterization of abnormalities on 68Ga-PSMA PET/CT imaging can be accomplished only if one is aware of the normal distribution pattern, physiological variants, and potential sources of false imaging findings. Altered biodistribution can have a significant impact on scan interpretation. Presented here is a rare case in which radiopharmaceutical radiolysis occurred causing excessive free 68Ga-citrate showing as an increased vascular activity. As 68Ga-PSMA PET/CT imaging is a relatively new imaging technique, it is important to be aware of such a potential technical pitfall in clinical practice in order to prevent scan misinterpretation.

Original languageEnglish
Pages (from-to)e203-e205
JournalClinical Nuclear Medicine
Volume43
Issue number6
DOIs
StatePublished - 1 Jun 2018
Externally publishedYes

Keywords

  • Ga-PSMA
  • Ga-citrate
  • PET/CT
  • altered biodistribution
  • radiolysis
  • technical pitfall

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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