Telomerase expression in adult and old mouse purkinje neurons

Erez Eitan, Ailon Tichon, Gitler Daniel, Esther Priel

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Telomerase promotes tissue regeneration by delaying the entrance of cells into senescence. Studies performed on cells or animals overexpressing telomerase reverse transcriptase (TERT), the catalytic subunit of telomerase, have revealed that TERT exhibits antiapoptotic effects in neurons. However, it is not clear whether endogenous TERT possesses these functions as well. Here we demonstrate the presence of active telomerase in the cytoplasm and nucleus of cerebellar Purkinje neurons of adult and old mice. TERT protein levels are reduced with age, whereas in the nucleus TERT activity is increased. These findings suggest that telomerase plays a role in the aging of nondividing cells.

Original languageEnglish
Pages (from-to)206-209
Number of pages4
JournalRejuvenation Research
Issue number2
StatePublished - 1 Apr 2012

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology


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