Temperature-dependent proteolysis as a control element in Escherichia coli metabolism

Chen Katz, Aviram Rasouly, Eyal Gur, Yotam Shenhar, Dvora Biran, Eliora Z. Ron

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Escherichia coli can grow at a broad temperature range, from less than 20 °C up to 45 °C. An increase in temperature results in a major physiological change, as enzymes work faster but, on the other hand, proteins tend to unfold. Therefore, a shift-up in temperature results in the induction of several regulatory response mechanisms aimed at restoring balanced growth at the new temperature. One important mechanism involves temperature-dependent proteolysis, which constitutes a fast response to temperature shift-ups. Here we discuss the effect of proteolysis on protein synthesis, and the heat shock response.

Original languageEnglish
Pages (from-to)684-686
Number of pages3
JournalResearch in Microbiology
Issue number9
StatePublished - 1 Nov 2009
Externally publishedYes


  • Heat shock response
  • Methionine biosynthesis
  • Protein degradation

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology


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