Abstract
(Chemical Equation Presented) No isolation, no purification. An efficient and simple method based on tetrabutylammonium fluoride-mediated alkylation without protecting groups in microtiter plates, followed by screening in situ has been developed to identify new enzyme inhibitors, as demonstrated in the discovery of the shown potent inhibitors of cathepsin B and HIV protease.
Original language | English |
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Pages (from-to) | 2176-2180 |
Number of pages | 5 |
Journal | ChemBioChem |
Volume | 6 |
Issue number | 12 |
DOIs | |
State | Published - 1 Dec 2005 |
Externally published | Yes |
Keywords
- Alkylation
- Chemistry esterification
- Combinatorial
- Inhibitors
- TBAF
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Organic Chemistry