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The Actin Network Interfacing Diverse Integrin-Mediated Adhesions

  • Benjamin Geiger
  • , Rajaa Boujemaa-Paterski
  • , Sabina E. Winograd-Katz
  • , Jubina Balan Venghateri
  • , Wen Lu Chung
  • , Ohad Medalia

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

The interface between the cellular actin network and diverse forms of integrin-mediated cell adhesions displays a unique capacity to serve as accurate chemical and mechanical sensors of the cell’s microenvironment. Focal adhesion-like structures of diverse cell types, podosomes in osteoclasts, and invadopodia of invading cancer cells display distinct morphologies and apparent functions. Yet, all three share a similar composition and mode of coupling between a protrusive structure (the lamellipodium, the core actin bundle of the podosome, and the invadopodia protrusion, respectively), and a nearby adhesion site. Cytoskeletal or external forces, applied to the adhesion sites, trigger a cascade of unfolding and activation of key adhesome components (e.g., talin, vinculin, integrin), which in turn, trigger the assembly of adhesion sites and generation of adhesion-mediated signals that affect cell behavior and fate. The structural and molecular mechanisms underlying the dynamic crosstalk between the actin cytoskeleton and the adhesome network are discussed.

Original languageEnglish
Article number294
JournalBiomolecules
Volume13
Issue number2
DOIs
StatePublished - 1 Feb 2023
Externally publishedYes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • actin
  • cell–matrix adhesions
  • focal adhesions
  • integrins
  • invadopodia
  • podosomes
  • vinculin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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