The addition of a glucocorticoid to the protocol of programmed oocyte retrieval for in-vitro fertilization - A randomized study

David Bider, Ida Amoday, Ilan Tur-Kaspa, Alexander Livshits, Jehoshua Dor

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

A group of 78 infertile women, diagnosed as having tubal factor infertility only, was enrolled in a prospective, randomized study conducted to determine whether the addition of different doses of glucocorticoids to the protocol of ovulation induction for in-vitro fertilization (IVF) would be beneficial. Oocyte numbers, percentage of fertilization, oestradiol, luteinizing hormone and follicle stimulating hormone serum concentrations, number of embryo transfers and pregnancy rate were evaluated. Compared to control cycles (group A; n = 24), the addition of 0.5 mg (group B; n = 27) or 1 mg dexamethasone (group C; n = 27), combined with the protocol of programmed oocyte retrieval for IVF patients in the study, demonstrated equivalent results. The mean numbers of oocytes retrieved were 10.8 ± 3.9 in the control group, compared to 11.2 ± 4.0 in group B and 10.5 ± 3.6 in group C. The fertilization rates were 69 ± 21, 66 ± 18 and 70 ± 15% respectively. The pregnancy rates were 20, 16 and 20.8% respectively. The addition of up to 1 mg dexamethasone daily to the protocol of ovulation induction for oocyte retrieval did not improve the overall IVF-embryo transfer outcome in patients with tubal factor infertility.

Original languageEnglish
Pages (from-to)1606-1608
Number of pages3
JournalHuman Reproduction
Volume11
Issue number8
DOIs
StatePublished - 1 Jan 1996
Externally publishedYes

Keywords

  • DEX
  • Embryo transfer
  • Ovulation induction

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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