The aging oocyte - Can mitochondrial function be improved?

Yaakov Bentov, Robert F. Casper

Research output: Contribution to journalReview articlepeer-review

85 Scopus citations

Abstract

In recent years, social and cultural trends have resulted in women delaying childbirth, thereby leading to reproductive senescence as a growing public health problem. We discuss potential etiologies for age-related female reproductive decline. We bring supportive evidence to the central role of mitochondrial dysfunction and oxygen radicals in the process of aging in general and reproductive senescence specifically. We also explore the role of coenzyme Q10 deficiency as a contributing factor and the effects of its administration.

Original languageEnglish
Pages (from-to)18-22
Number of pages5
JournalFertility and Sterility
Volume99
Issue number1
DOIs
StatePublished - 1 Jan 2013
Externally publishedYes

Keywords

  • Reproductive senescence
  • coenzyme Q10
  • mitochondrial dysfunction
  • mitochondrial nutrients
  • reactive oxygen species

Fingerprint

Dive into the research topics of 'The aging oocyte - Can mitochondrial function be improved?'. Together they form a unique fingerprint.

Cite this