The aging oocyte - Can mitochondrial function be improved?

Yaakov Bentov, Robert F. Casper

Research output: Contribution to journalReview articlepeer-review

85 Scopus citations


In recent years, social and cultural trends have resulted in women delaying childbirth, thereby leading to reproductive senescence as a growing public health problem. We discuss potential etiologies for age-related female reproductive decline. We bring supportive evidence to the central role of mitochondrial dysfunction and oxygen radicals in the process of aging in general and reproductive senescence specifically. We also explore the role of coenzyme Q10 deficiency as a contributing factor and the effects of its administration.

Original languageEnglish
Pages (from-to)18-22
Number of pages5
JournalFertility and Sterility
Issue number1
StatePublished - 1 Jan 2013
Externally publishedYes


  • Reproductive senescence
  • coenzyme Q10
  • mitochondrial dysfunction
  • mitochondrial nutrients
  • reactive oxygen species


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