The ambivalent effects of early and late administration of mannitol in cold-induced brain oedema.

E. Reichenthal; T. Kaspi; M. L. Cohen; I. Shevach; E. Shalmon; Y. Bar-Ziv; Z. Feldman; G. Zucker

doi:10.1007/978-3-7091-9115-6_37

The ambivalent effects of early and late administration of mannitol in cold-induced brain oedema.

E. Reichenthal, T. Kaspi, M. L. Cohen, I. Shevach, E. Shalmon, Y. Bar-Ziv, Z. Feldman, G. Zucker

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Abstract

This study was undertaken in order to determine whether early administration of mannitol is different from late administration in its effect on brain oedema. Cold-induced brain oedema, which was confirmed by high resolution CT scan, was produced in 2 groups of cats. In group one mannitol was given early (90 minutes after injury); in group two 3-4 hours after the injury (late). Repeated CT scans following mannitol administration showed that the early group exhibited significantly greater dehydration (p less than 0.0001) while the late group showed significant hydration, in the lesioned hemisphere. The contralateral control hemisphere responded to mannitol with similar dehydration effect in both groups.

Original language	English
Pages (from-to)	110-112
Number of pages	3
Journal	Acta Neurochirurgica, Supplementum
Volume	51
DOIs	https://doi.org/10.1007/978-3-7091-9115-6_37
State	Published - 1 Jan 1990

ASJC Scopus subject areas

Surgery
Clinical Neurology

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abstract = "This study was undertaken in order to determine whether early administration of mannitol is different from late administration in its effect on brain oedema. Cold-induced brain oedema, which was confirmed by high resolution CT scan, was produced in 2 groups of cats. In group one mannitol was given early (90 minutes after injury); in group two 3-4 hours after the injury (late). Repeated CT scans following mannitol administration showed that the early group exhibited significantly greater dehydration (p less than 0.0001) while the late group showed significant hydration, in the lesioned hemisphere. The contralateral control hemisphere responded to mannitol with similar dehydration effect in both groups.",

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AU - Cohen, M. L.

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AU - Shalmon, E.

AU - Bar-Ziv, Y.

AU - Feldman, Z.

AU - Zucker, G.

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AB - This study was undertaken in order to determine whether early administration of mannitol is different from late administration in its effect on brain oedema. Cold-induced brain oedema, which was confirmed by high resolution CT scan, was produced in 2 groups of cats. In group one mannitol was given early (90 minutes after injury); in group two 3-4 hours after the injury (late). Repeated CT scans following mannitol administration showed that the early group exhibited significantly greater dehydration (p less than 0.0001) while the late group showed significant hydration, in the lesioned hemisphere. The contralateral control hemisphere responded to mannitol with similar dehydration effect in both groups.

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The ambivalent effects of early and late administration of mannitol in cold-induced brain oedema.

Abstract

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