The ambivalent effects of early and late administration of mannitol in cold-induced brain oedema.

E. Reichenthal, T. Kaspi, M. L. Cohen, I. Shevach, E. Shalmon, Y. Bar-Ziv, Z. Feldman, G. Zucker

    Research output: Contribution to journalArticlepeer-review

    11 Scopus citations

    Abstract

    This study was undertaken in order to determine whether early administration of mannitol is different from late administration in its effect on brain oedema. Cold-induced brain oedema, which was confirmed by high resolution CT scan, was produced in 2 groups of cats. In group one mannitol was given early (90 minutes after injury); in group two 3-4 hours after the injury (late). Repeated CT scans following mannitol administration showed that the early group exhibited significantly greater dehydration (p less than 0.0001) while the late group showed significant hydration, in the lesioned hemisphere. The contralateral control hemisphere responded to mannitol with similar dehydration effect in both groups.

    Original languageEnglish
    Pages (from-to)110-112
    Number of pages3
    JournalActa Neurochirurgica, Supplement
    Volume51
    DOIs
    StatePublished - 1 Jan 1990

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