TY - JOUR
T1 - The ambivalent effects of early and late administration of mannitol in cold-induced brain oedema.
AU - Reichenthal, E.
AU - Kaspi, T.
AU - Cohen, M. L.
AU - Shevach, I.
AU - Shalmon, E.
AU - Bar-Ziv, Y.
AU - Feldman, Z.
AU - Zucker, G.
PY - 1990/1/1
Y1 - 1990/1/1
N2 - This study was undertaken in order to determine whether early administration of mannitol is different from late administration in its effect on brain oedema. Cold-induced brain oedema, which was confirmed by high resolution CT scan, was produced in 2 groups of cats. In group one mannitol was given early (90 minutes after injury); in group two 3-4 hours after the injury (late). Repeated CT scans following mannitol administration showed that the early group exhibited significantly greater dehydration (p less than 0.0001) while the late group showed significant hydration, in the lesioned hemisphere. The contralateral control hemisphere responded to mannitol with similar dehydration effect in both groups.
AB - This study was undertaken in order to determine whether early administration of mannitol is different from late administration in its effect on brain oedema. Cold-induced brain oedema, which was confirmed by high resolution CT scan, was produced in 2 groups of cats. In group one mannitol was given early (90 minutes after injury); in group two 3-4 hours after the injury (late). Repeated CT scans following mannitol administration showed that the early group exhibited significantly greater dehydration (p less than 0.0001) while the late group showed significant hydration, in the lesioned hemisphere. The contralateral control hemisphere responded to mannitol with similar dehydration effect in both groups.
UR - http://www.scopus.com/inward/record.url?scp=0025620223&partnerID=8YFLogxK
U2 - 10.1007/978-3-7091-9115-6_37
DO - 10.1007/978-3-7091-9115-6_37
M3 - Article
AN - SCOPUS:0025620223
VL - 51
SP - 110
EP - 112
JO - Acta Neurochirurgica, Supplement
JF - Acta Neurochirurgica, Supplement
SN - 0065-1419
ER -