The anti-leukaemic activity of novel synthetic naphthoquinones against acute myeloid leukaemia: Induction of cell death via the triggering of multiple signalling pathways

Keyphrases

• Acute Myeloid Leukemia 100%
• Cell Death 100%
• Multiple Signaling Pathways 100%
• Naphthoquinone 100%
• Apoptosis 66%
• Pro-apoptotic 66%
• Phenyl 66%
• Hydrogen Peroxide 33%
• Cancer Chemotherapy 33%
• In Cancer 33%
• Amino 33%
• Amines 33%
• Low Toxicity 33%
• Incubation 33%
• Mitochondrial Membrane Potential 33%
• Mitochondria 33%
• Phosphorylation 33%
• NADPH Oxidase 33%
• P38 Mitogen-activated Protein Kinase (p38 MAPK) 33%
• Anti-apoptotic 33%
• Apoptotic Cell Death 33%
• Methyl 33%
• Chloro 33%
• Regulatory Proteins 33%
• Rat Liver Mitochondria 33%
• Cytochrome c Release 33%
• Necrotic Cell Death 33%
• Intact Cells 33%
• Menadione 33%
• Isolated Rat Liver 33%
• U937 33%
• ERK2 33%
• Leukaemic Cells 33%
• Myeloid Cell leukemia-1 (Mcl-1) 33%
• Anthracyclins 33%
• Extracellular Regulated Protein Kinases 33%
• Structure-activity Relationship Studies 33%
• Caspase Activation 33%
• Benzoic 33%
• Glutathione Depletion 33%
• Iodonium 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Acute Myeloid Leukemia 100%
• Antileukemic Agent 100%
• Naphthoquinone 100%
• Leukemogenesis 100%
• Cancer Chemotherapy 33%
• Reduced Nicotinamide Adenine Dinucleotide Phosphate Oxidase 33%
• Glutathione 33%
• Mitogen Activated Protein Kinase P38 33%
• Caspase 33%
• Antiapoptotic 33%
• Cytochrome C 33%
• Structure Activity Relationship 33%
• Regulator Protein 33%
• Menadione 33%
• Anthracycline 33%
• Mitogen Activated Protein Kinase 3 33%