The association between sarcoidosis and ischemic heart disease—a healthcare analysis of a large israeli population

Tal Gonen, Daphna Katz-Talmor, Howard Amital, Doron Comaneshter, Arnon D. Cohen, Shmuel Tiosano

Research output: Contribution to journalArticlepeer-review

Abstract

(1) Background: Inflammation plays a pivotal role in atherosclerosis, and the association between chronic inflammatory states and ischemic heart disease (IHD) has been shown in several rheumatic diseases. Persistent inflammation might also be a risk factor for IHD in sarcoidosis patients. (2) Methods: Demographic and clinical data of 3750 sarcoidosis patients and 18,139 age-and sex-matched controls were retrieved from the database of Clalit Health Services, Israel’s largest healthcare organization. Variables associated with IHD were assessed by a logistic regression model. To assess for variables that were related to increased risk of all-cause mortality, the Cox proportional hazards method was used, and a log-rank test was performed for survival analysis. (3) Results: Both groups were composed of 64% females with a median age of 56 years. An association between sarcoidosis and IHD was demonstrated by a multivariate analysis (adjusted odds ratio (OR) 1.5; 95% confidence interval (CI) 1.36–1.66). Long-term follow-up revealed increased mortality among sarcoidosis patients: 561 (15%) deaths compared to 1636 (9%) deaths among controls (p < 0.001). Survival analysis demonstrated that sarcoidosis patients were also at increased risk for all-cause mortality compared to controls (multivariate model, adjusted HR 1.93; 95% CI 1.76–2.13).

Original languageEnglish
Article number5067
JournalJournal of Clinical Medicine
Volume10
Issue number21
DOIs
StatePublished - 1 Nov 2021

Keywords

  • Comorbidities
  • Ischemic heart disease
  • Sarcoidosis

Fingerprint

Dive into the research topics of 'The association between sarcoidosis and ischemic heart disease—a healthcare analysis of a large israeli population'. Together they form a unique fingerprint.

Cite this