The association of quantitative EEG and MRI in Creutzfeldt-Jakob Disease

Shmuel Appel, Oren S. Cohen, Joab Chapman, Shlomo Gilat, Hanna Rosenmann, Zeev Nitsan, Ester Kahan, Ilan Blatt

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Introduction: Previous studies showed concordance between the typical Periodic Sharp Wave Complex (PSWC) activity in EEG of Creutzfeldt-Jakob Disease (CJD) patients and the MRI findings, while the concordance with slow activity in EEG is less established. The aim of this study was to better characterize the association between MRI findings and EEG changes using quantitative EEG (qEEG) analysis. Methods: The demographics, clinical features, and the MRI findings of 12 familial E200K patients with CJD were gathered. EEG test was done and reviewed for the typical PSWC and for the non-specific slow activity. A possible association between the MRI findings and the EEG activity was examined. Then, EEG was analyzed using qEEG tool, and the association between the qEEG finding and the MRI was examined. Results: Twelve patients were included in the study (67% women). Cortical MRI lesions finding were seen in 6/12 (50%) of the patients, and deep gray mater lesions were seen in 8/12 patients (67%). EEG showed the classic PSWC in 6/12 (50%) of the patients where slow activity was seen in 10/12 (83%). Slow activity and cortical MRI findings were associated in only 2/6 (33%) where deep gray matter findings and the slow activity had concordance of 4/8 (50%). qEEG analysis improved this concordance between slow activity and cortical findings to 3/6 (50%) and with the deep gray matter findings to 5/8 (63%). Conclusions: Quantitative EEG analysis modesty but not significantly, improves the association of EEG slow activity in familial E200K CJD patients with MRI findings.

Original languageEnglish
Pages (from-to)366-371
Number of pages6
JournalActa Neurologica Scandinavica
Issue number5
StatePublished - 1 Nov 2019


  • Creutzfeldt- Jakob Disease
  • association
  • electroencephalogram
  • magnetic resonance imaging
  • quantitative EEG

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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