The base-catalysed rearrangement of O-propargyl ketoximes to N-1-alkenyl acryl amides

Boris A. Trofimov, Ol'ga A. Tarasova, Mark V. Sigalov, Al'bina I. Mikhaleva

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

O-Propargyl ketoximes, available from the reaction of ketoximes with propargyl halides in KOH/DMSO system, readily undergo base-catalysed (t-BuOK in DMSO or THF) rearrangement to N-(1-alkenyl)acrylamides in 15-58 % yields.

Original languageEnglish
Pages (from-to)9181-9184
Number of pages4
JournalTetrahedron Letters
Volume36
Issue number50
DOIs
StatePublished - 11 Dec 1995
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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